{"id":14866,"date":"2021-08-03T00:00:00","date_gmt":"2021-08-03T00:00:00","guid":{"rendered":"https:\/\/cms.alj3.clients.lemonhq.io\/perspectives\/ortakliklar-yoluyla-ilerlemeyi-destekleme\/"},"modified":"2026-05-12T13:31:41","modified_gmt":"2026-05-12T13:31:41","slug":"ortakliklar-yoluyla-ilerlemeyi-destekleme","status":"publish","type":"perspectives","link":"https:\/\/cms.alj3.clients.lemonhq.io\/tr\/perspectives\/ortakliklar-yoluyla-ilerlemeyi-destekleme\/","title":{"rendered":"Ortakl\u0131klar yoluyla ilerlemeyi destekleme"},"content":{"rendered":"<h4>A Q&amp;A with Prof. James J. Collins, newly appointed special advisor to Abdul Latif Jameel Health<\/h4>\n<p>As part of its mission to improve accessibility to high quality healthcare around the world, <a href=\"https:\/\/aljhealth.com\">Abdul Latif Jameel Health<\/a> is continually looking to forge partnerships with the leading organizations, researchers innovators and thinkers in the global biotech and health industries.<\/p>\n<p>In May 2021, it appointed Professor James J. Collins as a special advisor. \u00a0James is the <a href=\"https:\/\/be.mit.edu\/directory\/james-j-collins\">Termeer Professor of Medical Engineering &amp; Science<\/a> in the Institute for Medical Engineering &amp; Science (<a href=\"https:\/\/imes.mit.edu\/\">IMES<\/a>) and Department of Biological Engineering at the Massachusetts Institute of Technology (<a href=\"https:\/\/mit.edu\/\">MIT<\/a>).<\/p>\n<p>His innovative research group works in synthetic and systems biology, developing novel and pioneering ways to \u2018reprogram\u2019 organisms, including bacteria, to perform targeted tasks, such as detecting and treating infections. \u00a0This may lead to cheaper drugs, rapid diagnostic tests, and more effective treatments for antibiotic-resistant infections and a range of complex diseases.<\/p>\n<div id=\"attachment_53485\" style=\"width: 310px\" class=\"wp-caption alignright\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-53485\" class=\"size-medium wp-image-53485\" src=\"https:\/\/www.alj.com\/app\/uploads\/2019\/11\/J-Clinic-Leadership-300x182.jpg\" alt=\"Meet the J-Clinic leadership team (L-R): Phillip A. Sharp, Chair, Advisory Board; James J. Collins &amp; Regina Barizlay, Faculty Leads; Anantha P. Chandrakasan, Chair, J-Clinic.\" width=\"300\" height=\"182\" \/><p id=\"caption-attachment-53485\" class=\"wp-caption-text\">James Collins and Regina Barzilay (center) were named as inaugural faculty co-leads of the Abdul Latif Jameel Clinic for Machine Learning in Health, (Jameel Clinic), by Anantha Chandrakasan (right), Dean of MIT School of Engineering and Jameel Clinic Chair with Prof. Philip Sharp (left) Chair of the Clinic\u2019s advisory Board \u2013 October 2018.<\/p><\/div>\n<p>Along with MIT colleague Regina Barzilay, James is a <a href=\"https:\/\/news.mit.edu\/2018\/mit-barzilay-collins-sharp-lead-j-clinic-machine-learning-health-1003\">faculty co-lead<\/a> of the Abdul Latif Jameel Clinic for Machine Learning in Health, (<a href=\"https:\/\/www.jclinic.mit.edu\/\">Jameel Clinic<\/a>) at <a href=\"https:\/\/mit.edu\">MIT<\/a> since its founding in 2018.<\/p>\n<p>We spoke to Professor Collins about his research, his new role at Abdul Latif Jameel Health, and his vision for the future of global healthcare.<\/p>\n<h2>Could you provide a brief overview of your current work?<\/h2>\n<p>I am the Termeer Professor of Medical Engineering and Science in the Institute for Medical Engineering and Science as well as the Department of Biological Engineering.\u00a0 I am also co-faculty lead of the Jameel Clinic, which was established with a generous gift from <a href=\"https:\/\/www.alj.com\/en\/our-people\/mohammed-abdul-latif-jameel\/\">Mohammed Jameel<\/a> and his family to serve as a nexus point for efforts at MIT focused on applying AI to the challenges of healthcare.<\/p>\n<p>In addition to my position at MIT, I am also a founding core faculty member of the <a href=\"https:\/\/wyss.harvard.edu\/\">Wyss Institute at Harvard<\/a> and an Institute Member at the <a href=\"https:\/\/www.broadinstitute.org\/\">Broad Institute<\/a> of MIT and Harvard.\u00a0 My lab primarily focuses on two areas:\u00a0 synthetic biology and antibiotics research, two areas that are increasingly tapping into the potential of AI to advance our knowledge and capabilities.<\/p>\n<h2>When did you first become aware of Abdul Latif Jameel Health?<\/h2>\n<p>I quickly became connected with Mohammed Jameel and the <a href=\"https:\/\/www.communityjameel.org\/en\/who-we-are\/jameel-family\">Jameel Family<\/a>, together with <a href=\"https:\/\/www.communityjameel.org\">Community Jameel<\/a>, and their broader interests in translational healthcare research. \u00a0It was probably within a year of my involvement with the Jameel Clinic that I became aware of <a href=\"https:\/\/aljhealth.com\">Abdul Latif Jameel Health<\/a> more specifically. \u00a0Its mission resonates closely with my own approach.\u00a0 I was delighted to be asked to join as an advisor.\u00a0 My role is primarily to help Abdul Latif Jameel Health evaluate exciting opportunities for either investment or partnerships, such as the recent link-ups with <a href=\"https:\/\/www.alj.com\/en\/perspective\/a-stomach-for-innovation-a-qa-with-ceos-of-evelo-biosciences-and-abdul-latif-jameel-health-on-their-exciting-new-adventure\/\">Evelo Biosciences<\/a> and Cellarity.<\/p>\n<h2>What do you see as the biggest challenges facing global healthcare currently?<\/h2>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-90851\" src=\"https:\/\/www.alj.com\/app\/uploads\/2021\/08\/Prof-James-J.-Collins-test-tube-192x300.jpg\" alt=\"Prof James J. Collins\" width=\"192\" height=\"300\" \/>Most people think of global health challenges as being exclusively around infectious diseases. \u00a0In my own field, we work in infectious diseases, particularly antibiotics and increasingly now antivirals as a result of the COVID-19 pandemic.\u00a0 But an under-appreciated aspect is that developing countries are also saddled with major challenges around non-infectious diseases, including cancer and nerve degenerative conditions.<\/p>\n<p>So, the bigger challenge is how to make the marvelous advances that we are seeing in both infectious and non-infectious diseases affordable and accessible to everybody.<\/p>\n<p>Traditionally, most of the effort around global public health has been in the non-profit sphere. \u00a0One of the missions of Abdul Latif Jameel Health is to see how it can be achieved from a <em>for-profit<\/em> perspective, leveraging the ability of market forces and market encouragement to drive meaningful change.<\/p>\n<p>At a personal level, many of my interests are in infectious disease, but we are increasingly looking to see how various tools from AI and synthetic biology can address other more complex diseases and may lend themselves well to addressing broader health challenges around the globe.<\/p>\n<h2>Could you provide some examples of how technologies like AI, big data and machine learning are advancing innovation on healthcare?<\/h2>\n<div id=\"attachment_57741\" style=\"width: 310px\" class=\"wp-caption alignright\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-57741\" class=\"size-medium wp-image-57741\" src=\"https:\/\/www.alj.com\/app\/uploads\/2020\/02\/halicin-antibiotics-300x300.jpg\" alt=\"Halicin\" width=\"300\" height=\"300\" \/><p id=\"caption-attachment-57741\" class=\"wp-caption-text\">The now famous MIT image showing Halicin (top) preventing antibiotic resistance in E. coli, ciprofloxacin (bottom) did not.<\/p>\n<p>Photo Credit \u00a9 courtesy Collins Lab at MIT<\/p><\/div>\n<p>If we take antibiotics first, as part of the Jameel Clinic, Regina Barzilay, Tommi Jaakkola and myself collaborated to see if we could harness the power of AI to address the antibiotic resistance crisis.\u00a0 We were able to advance a pilot effort where we trained an AI model to help us identify a potent new antibiotic called <a href=\"https:\/\/www.alj.com\/en\/news\/j-clinic-discovers-powerful-new-antibiotic-using-ai-technology\/\">Halicin<\/a> that was very effective against a broad range of pathogens, including multi-drug resistant, extensively drug-resistant and pan-resistant pathogens.<\/p>\n<p>We were subsequently able to apply the model to an enormous library of 1.5 billion molecules in just a few days, identifying a large number of other new antibiotic candidates.<\/p>\n<p>We have now launched the Antibiotics-AI project at MIT through the Jameel Clinic, with the goal of using AI to design and discover a novel class of antibiotics, as we did with Halicin.<\/p>\n<p>On the synthetic biology side, we have previously established that you can use engineered synthetic gene circuits along with cell-free extracts.\u00a0 In the case of cell-free systems, you can open up a living cell and take the \u2018machinery\u2019 out of that cell.\u00a0 Our advance was to show you could freeze-dry these cell-free extract along with synthetic biology gene circuits onto paper in order to create inexpensive paper based diagnostics.<\/p>\n<p>Perhaps most stunningly, in the midst of the COVID-19 pandemic and under the auspices of the Jameel Clinic, in part, we showed we could use synthetic biology to create a COVID-19 facemask diagnostic that could give an output in a relatively few minutes with high sensitivity and high specificity to SARS-CoV-2.\u00a0 In short, a facemask which could tell you if you had COVID-19.<\/p>\n<h2>How close to commercialization are these advances?<\/h2>\n<p>With Halicin, we are now advancing it further towards a potential clinical trial; exploring its toxicity, developing analogues to address the toxicity, and scoping out additional aspects of its drug-like properties.<\/p>\n<p>With regard to the paper-based diagnostic, we have a spinout from MIT, <a href=\"https:\/\/sherlock.bio\/\">Sherlock Biosciences<\/a>, which has developed an <a href=\"https:\/\/sherlock.bio\/sherlock-biosciences-receives-fda-emergency-use-authorization-for-crispr-sars-cov-2-rapid-diagnostic\/\">FDA-approved COVID-19 diagnostic based on our synthetic biology platform<\/a>.\u00a0 This has now been adopted by multiple global diagnostic firms, as well as the country of Nepal as their national test. Sherlock Biosciences and its partners are now on pace to use our technology to conduct 10M COVID-19 diagnostic tests each month in countries around the globe.<\/p>\n<p>The diagnostic facemask is still at the academic stage.\u00a0 It is not yet commercialized, but it is an interesting opportunity to explore as to how could we move this from a lab demo at MIT and the Wyss Institute to a product that might be available at your local pharmacy.<\/p>\n<h2>How important is it to make sure that innovations like these get out into the whole world and don\u2019t only become healthcare for wealthy nations?<\/h2>\n<p>It is an important part of my mission as a professor and an entrepreneur to try and ensure that our technologies are available to all.\u00a0 We too often see companies that are driven for profit over impact, particularly in the US.\u00a0 For me, impact is much more important than profit.\u00a0 I would much rather see a product that benefits millions of individuals than make millions of dollars off the product.<\/p>\n<h2>Has the COVID-19 pandemic encouraged people to think more about this aspect?<\/h2>\n<p>It has, but not as much as it should.\u00a0 Greed is unfortunately a very powerful force in this world.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignright size-full wp-image-90844\" src=\"https:\/\/www.alj.com\/app\/uploads\/2021\/08\/Logo.jpg\" alt=\"221B Foundation Logo\" width=\"195\" height=\"88\" \/>This is why, through Sherlock Biosciences, we have established a foundation called The <a href=\"https:\/\/221bfoundation.org\/\">221b Foundation<\/a>, named after Sherlock Holmes\u2019 fictional address in London.<\/p>\n<p>We have committed to donating all profits from our COVID-19 product to the foundation, as well as making all our IP around CRISPR diagnostics available to any organization that would like to develop COVID-19 diagnostics, on the understanding that the profits need to come back to the foundation.<\/p>\n<p>These profits are then dedicated to advancing STEM (Science, Technology, Engineering and Mathematics) efforts for under-represented minorities, trying to encourage more young people to study STEM subjects, to advance technologies and to address global health challenges.<\/p>\n<h2>How is the Jameel Clinic as a whole helping to address some of these issues?<\/h2>\n<div id=\"attachment_53565\" style=\"width: 310px\" class=\"wp-caption alignright\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-53565\" class=\"size-medium wp-image-53565\" src=\"https:\/\/www.alj.com\/app\/uploads\/2019\/11\/Hassan-Jameel-JClinic-300x200.jpg\" alt=\"Jameel Clinic\" width=\"300\" height=\"200\" \/><p id=\"caption-attachment-53565\" class=\"wp-caption-text\">Hassan Jameel (L), L. Rafael Reif, President MIT (C) and Fady Jameel (R) at the foundation ceremony of the Jameel Clinic at MIT, 2018.<\/p><\/div>\n<p>The Jameel Clinic was formed approximately three years ago [2018], and it has been thriving since then, with a number of exciting programs underway.<\/p>\n<p>In the midst of the pandemic, the Clinic launched a program called AI Cures, which aims to advance AI to address emerging pathogens, including SARS-CoV-2.\u00a0 As part of this initiative, we were able to pull together a number of interesting datasets that were made accessible to researchers around the world.<\/p>\n<p>Working with Regina Barzilay and Tommi Jaakkola and a number of their graduate students, we were also able to use AI, for example, to develop effective combinations for treating SARS-CoV-2, the pathogen that causes COVID-19.<\/p>\n<h2>What is it about AI, big data and machine learning that makes them such gamechangers in healthcare innovation?<\/h2>\n<p>The key aspect to AI and big data is that these resources enable us to embrace the complexity of biology and chemistry at a scale well beyond anything our brains alone could achieve.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-87903\" src=\"https:\/\/www.alj.com\/app\/uploads\/2021\/04\/James-J-Collins-T-300x162.jpg\" alt=\"James J Collins\" width=\"300\" height=\"162\" \/>Even the simplest of living cells, bacteria, are much more complicated than the most complicated machine we have ever designed on Earth.\u00a0 It is effectively impossible to comprehensively understand how such a living system evolved over the course of billions of years.<\/p>\n<p>Similarly, it is incredibly difficult to understand how a drug that we are developing could affect the complex biology of a living cell or set of cells.\u00a0 Big data and AI enable us to do that.\u00a0 We can use these technologies to query the biology of a living cell at a scale that we previously could not.\u00a0 It enables us to understand the interaction between molecules to generate better insights into how all these amazing components in a living cell interact to create a healthy state and how they might break down in their interactions to create a disease state.\u00a0 This allows us to identify how we could potentially intervene to correct or improve upon a diseased or injured state.<\/p>\n<h2>Is the potential of these technologies yet fully understood?<\/h2>\n<p>Not at all, we are still very early days in applying AI to challenges in health care.\u00a0 We have seen AI and big data have a huge impact in the information world and the internet, but in the fields of biology and medicine, the age of big data is still in its infancy.\u00a0 I think we will see increasing advancements in the next decade or two as more and more data are collected and made available.\u00a0 One of our missions at the Jameel Clinic is to train the next generation of healthcare researchers to be multi-disciplinary, so they have expertise in both AI\/machine learning and in biology and chemistry, allowing them to work at the interface of technology, science and medicine to make breakthroughs that matter for patients.<\/p>\n<h2>Looking ahead, what do you think the medium-to-longer-term future of global health care looks like?<\/h2>\n<p>I think one of the few advantages of the pandemic is a growing awareness among young people of the importance of infectious disease as a serious issue worthy of their attention. \u00a0So, I think we will see more young talent coming into the field of infectious diseases and global health, which will certainly advance our knowledge and our abilities to detect, treat and prevent infections.<\/p>\n<p>Looking ahead, we will certainly see dramatic, impressive changes and advances in biomedicine.\u00a0 We will see the growing impact of big data, advanced technologies including AI and synthetic biology, to advance efforts that enable us to better diagnose disease, treat disease, and prevent disease across the globe, in a way that is economically efficient and hopefully affordable to all.<\/p>\n","protected":false},"featured_media":14852,"menu_order":0,"template":"","class_list":["post-14866","perspectives","type-perspectives","status-publish","has-post-thumbnail","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.5 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Ortakl\u0131klar yoluyla ilerlemeyi destekleme - Abdul Latif Jameel<\/title>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Ortakl\u0131klar yoluyla ilerlemeyi destekleme - Abdul Latif Jameel\" \/>\n<meta property=\"og:description\" content=\"A Q&amp;A with Prof. James J. Collins, newly appointed special advisor to Abdul Latif Jameel Health As part of its mission to improve accessibility to high quality healthcare around the world, Abdul Latif Jameel Health is continually looking to forge partnerships with the leading organizations, researchers innovators and thinkers in the global biotech and health [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/cms.alj3.clients.lemonhq.io\/tr\/perspectives\/ortakliklar-yoluyla-ilerlemeyi-destekleme\/\" \/>\n<meta property=\"og:site_name\" content=\"Abdul Latif Jameel\" \/>\n<meta property=\"article:modified_time\" content=\"2026-05-12T13:31:41+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/media.alj3.clients.lemonhq.io\/wp-content\/uploads\/2024\/10\/Prof-James-J.-Collins.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"2067\" \/>\n\t<meta property=\"og:image:height\" content=\"1176\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Tahmini okuma s\u00fcresi\" \/>\n\t<meta name=\"twitter:data1\" content=\"11 dakika\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/cms.alj3.clients.lemonhq.io\/tr\/perspectives\/ortakliklar-yoluyla-ilerlemeyi-destekleme\/\",\"url\":\"https:\/\/cms.alj3.clients.lemonhq.io\/tr\/perspectives\/ortakliklar-yoluyla-ilerlemeyi-destekleme\/\",\"name\":\"Ortakl\u0131klar yoluyla ilerlemeyi destekleme - Abdul Latif Jameel\",\"isPartOf\":{\"@id\":\"https:\/\/10.0.2.222\/en\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/cms.alj3.clients.lemonhq.io\/tr\/perspectives\/ortakliklar-yoluyla-ilerlemeyi-destekleme\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/cms.alj3.clients.lemonhq.io\/tr\/perspectives\/ortakliklar-yoluyla-ilerlemeyi-destekleme\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/media.alj3.clients.lemonhq.io\/wp-content\/uploads\/2024\/10\/Prof-James-J.-Collins.jpg\",\"datePublished\":\"2021-08-03T00:00:00+00:00\",\"dateModified\":\"2026-05-12T13:31:41+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/cms.alj3.clients.lemonhq.io\/tr\/perspectives\/ortakliklar-yoluyla-ilerlemeyi-destekleme\/#breadcrumb\"},\"inLanguage\":\"tr\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/cms.alj3.clients.lemonhq.io\/tr\/perspectives\/ortakliklar-yoluyla-ilerlemeyi-destekleme\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"tr\",\"@id\":\"https:\/\/cms.alj3.clients.lemonhq.io\/tr\/perspectives\/ortakliklar-yoluyla-ilerlemeyi-destekleme\/#primaryimage\",\"url\":\"https:\/\/media.alj3.clients.lemonhq.io\/wp-content\/uploads\/2024\/10\/Prof-James-J.-Collins.jpg\",\"contentUrl\":\"https:\/\/media.alj3.clients.lemonhq.io\/wp-content\/uploads\/2024\/10\/Prof-James-J.-Collins.jpg\",\"width\":2067,\"height\":1176},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/cms.alj3.clients.lemonhq.io\/tr\/perspectives\/ortakliklar-yoluyla-ilerlemeyi-destekleme\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/10.0.2.222\/en\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Ortakl\u0131klar yoluyla ilerlemeyi destekleme\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/10.0.2.222\/en\/#website\",\"url\":\"https:\/\/10.0.2.222\/en\/\",\"name\":\"Abdul Latif Jameel\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/10.0.2.222\/en\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"tr\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Ortakl\u0131klar yoluyla ilerlemeyi destekleme - Abdul Latif Jameel","robots":{"index":"noindex","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"og_locale":"tr_TR","og_type":"article","og_title":"Ortakl\u0131klar yoluyla ilerlemeyi destekleme - Abdul Latif Jameel","og_description":"A Q&amp;A with Prof. James J. 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Collins ile Soru-Cevap<\/h4>\r\n<p><a href=\"https:\/\/aljhealth.com\">Abdul Latif Jameel Health<\/a>, d\u00fcnya genelinde y\u00fcksek kaliteli sa\u011fl\u0131k hizmetlerine eri\u015filebilirli\u011fi iyile\u015ftirme misyonunun bir par\u00e7as\u0131 olarak, k\u00fcresel biyoteknoloji ve sa\u011fl\u0131k sekt\u00f6rlerindeki \u00f6nde gelen kurulu\u015flar, ara\u015ft\u0131rmac\u0131lar ve d\u00fc\u015f\u00fcn\u00fcrlerle s\u00fcrekli olarak ortakl\u0131klar kurmay\u0131 hedeflemektedir.<\/p>\r\n<p>May\u0131s 2021\u2019de Profes\u00f6r James J. Collins\u2019i \u00f6zel dan\u0131\u015fman olarak atam\u0131\u015ft\u0131r. James, T\u0131p M\u00fchendisli\u011fi ve Bilimi Enstit\u00fcs\u00fc (<a href=\"https:\/\/imes.mit.edu\/\">IMES<\/a>) <a href=\"https:\/\/be.mit.edu\/directory\/james-j-collins\">Termeer T\u0131p M\u00fchendisli\u011fi ve Bilimi B\u00f6l\u00fcm\u00fc\u2019nde Profes\u00f6rd\u00fcr<\/a> ve Massachusetts Institute of Technology (<a href=\"https:\/\/mit.edu\/\">MIT<\/a>) Biyoloji M\u00fchendisli\u011fi B\u00f6l\u00fcm\u00fc\u2019nde g\u00f6rev yapmaktad\u0131r.<\/p>\r\n<p>Yenilik\u00e7i ara\u015ft\u0131rma grubu, bakteriler de dahil olmak \u00fczere organizmalar\u0131 \u201cyeniden programlamak\u201d i\u00e7in yeni ve \u00f6nc\u00fc y\u00f6ntemler geli\u015ftirerek enfeksiyonlar\u0131 tespit etmek ve tedavi etmek gibi hedeflenen g\u00f6revleri yerine getirmek \u00fczere sentetik ve sistem biyolojisi \u00fczerinde \u00e7al\u0131\u015fmaktad\u0131r. Bu; ila\u00e7lar\u0131n daha da ucuzlamas\u0131, h\u0131zl\u0131 tan\u0131 testleri ve antibiyoti\u011fe diren\u00e7li enfeksiyonlar ve \u00e7e\u015fitli kompleks hastal\u0131klar i\u00e7in daha etkili tedaviler gibi imkanlar sa\u011flayabilecektir.<\/p>\r\n\r\n[caption id=\"attachment_53491\" align=\"alignright\" width=\"300\"]<img class=\"size-medium wp-image-53491\" src=\"https:\/\/www.alj.com\/app\/uploads\/2019\/11\/J-Clinic-Leadership-300x182.jpg\" alt=\"Meet the J-Clinic leadership team (L-R):  Phillip A. Sharp, Chair, Advisory Board; James J. Collins &amp; Regina Barizlay, Faculty Leads; Anantha P. Chandrakasan, Chair, J-Clinic.\" width=\"300\" height=\"182\" \/> James Collins ve Regina Barzilay (ortada) MIT M\u00fchendislik Fak\u00fcltesi Dekan\u0131 ve Jameel Clinic Ba\u015fkan\u0131 Anantha Chandrakasan (sa\u011fda) ve Klini\u011fin Dan\u0131\u015fma Kurulu Ba\u015fkan\u0131 Prof. Philip Sharp taraf\u0131ndan Abdul Latif Jameel Clinic\u2019in a\u00e7\u0131l\u0131\u015f \u00f6\u011fretim kadrosunda e\u015f ba\u015fkan olarak se\u00e7ildiler \u2013 Ekim 2018.[\/caption]\r\n\r\n<p>James, MIT \u00e7al\u0131\u015fan\u0131 Regina Barzilay ile birlikte, 2018 y\u0131l\u0131nda kurulu\u015fundan bu yana <a href=\"https:\/\/news.mit.edu\/2018\/mit-barzilay-collins-sharp-lead-j-clinic-machine-learning-health-1003\">MIT<\/a>\u2019te Abdul Latif Jameel Sa\u011fl\u0131kta Makine \u00d6\u011frenimi Klini\u011fi\u2019nin (<a href=\"https:\/\/www.jclinic.mit.edu\/\">Jameel Clinic<\/a>) <a href=\"https:\/\/mit.edu\">fak\u00fclte e\u015f ba\u015fkan\u0131d\u0131r.<\/a><\/p>\r\n<p>Profes\u00f6r Collins ile ara\u015ft\u0131rmalar\u0131, Abdul Latif Jameel Health\u2019teki yeni rol\u00fc ve k\u00fcresel sa\u011fl\u0131k hizmetinin gelece\u011fine ili\u015fkin vizyonu hakk\u0131nda konu\u015ftuk.<\/p>\r\n<h2>Mevcut \u00e7al\u0131\u015fmalar\u0131n\u0131z\u0131 k\u0131saca \u00f6zetleyebilir misiniz?<\/h2>\r\n<p>T\u0131p M\u00fchendisli\u011fi ve Bilimi Enstit\u00fcs\u00fc (IMES) Termeer T\u0131p M\u00fchendisli\u011fi ve Bilimi B\u00f6l\u00fcm\u00fc\u2019nde Profes\u00f6r\u00fcm ve Massachusetts Institute of Technology (MIT) Biyoloji M\u00fchendisli\u011fi B\u00f6l\u00fcm\u00fc\u2019nde g\u00f6rev yapmaktay\u0131m. Ayr\u0131ca, sa\u011fl\u0131k hizmetlerindeki zorluklar\u0131 a\u015fmak i\u00e7in yapay zeka uygulamalar\u0131na odaklanan bir ba\u011flant\u0131 noktas\u0131 olarak hizmet vermek \u00fczere MIT\u2019teki \u00e7al\u0131\u015fmalar i\u00e7in <a href=\"https:\/\/www.alj.com\/en\/our-people\/mohammed-abdul-latif-jameel\/\">Mohammed Jameel<\/a> ve ailesinden c\u00f6mert bir hediye ile kurulan Jameel Clinic\u2019in \u00f6\u011fretim kadrosu e\u015f ba\u015fkan\u0131y\u0131m.<\/p>\r\n<p>MIT\u2019teki pozisyonuma ek olarak <a href=\"https:\/\/wyss.harvard.edu\/\">Harvard Wyss Enstit\u00fcs\u00fc<\/a> ana \u00f6\u011fretim \u00fcyesi, MIT <a href=\"https:\/\/www.broadinstitute.org\/\">Broad Institute<\/a> ve Harvard Enstit\u00fc \u00dcyesiyim. Laboratuvar\u0131m \u00f6ncelikli olarak iki alana odaklan\u0131yor: sentetik biyoloji ve antibiyotik ara\u015ft\u0131rmas\u0131. Bunlar, bilgimizi ve kabiliyetlerimizi geli\u015ftirmek i\u00e7in yapay zekan\u0131n potansiyelinden giderek daha fazla yararlanan iki aland\u0131r.<\/p>\r\n<h2>Abdul Latif Jameel Health\u2019in ilk ne zaman fark\u0131na vard\u0131n\u0131z?<\/h2>\r\n<p><a href=\"https:\/\/www.communityjameel.org\/en\/who-we-are\/jameel-family\">Community Jameel <\/a>ve onlar\u0131n d\u00f6n\u00fc\u015f\u00fcmsel sa\u011fl\u0131k hizmeti ara\u015ft\u0131rmas\u0131na olan b\u00fcy\u00fck ilgileri sayesinde Mohammed Jameel ve <a href=\"https:\/\/www.communityjameel.org\">Jameel Ailesi <\/a>ile h\u0131zla ba\u011flant\u0131 kurdum. <a href=\"https:\/\/aljhealth.com\">Abdul Latif Jameel Health<\/a>\u2019in daha spesifik olarak fark\u0131na varmam muhtemelen Jameel Clinic\u2019e kat\u0131l\u0131mdan sonraki bir y\u0131l i\u00e7inde oldu. Misyonu, benim kendi yakla\u015f\u0131m\u0131mla yak\u0131ndan ili\u015fkili. Bir dan\u0131\u015fman olarak kat\u0131lmam\u0131 istemelerinden \u00f6t\u00fcr\u00fc b\u00fcy\u00fck memnuniyet duydum. Buradaki rol\u00fcm, \u00f6ncelikle Abdul Latif Jameel Health\u2019in <a href=\"https:\/\/www.alj.com\/en\/perspective\/a-stomach-for-innovation-a-qa-with-ceos-of-evelo-biosciences-and-abdul-latif-jameel-health-on-their-exciting-new-adventure\/\">Evelo Biosciences<\/a> ve Cellarity ile yak\u0131n zamandaki ba\u011flant\u0131lar gibi yat\u0131r\u0131m veya ortakl\u0131klar i\u00e7in heyecan verici f\u0131rsatlar\u0131 de\u011ferlendirmesine yard\u0131mc\u0131 olmak.<\/p>\r\n<h2>\u015eu anda k\u00fcresel sa\u011fl\u0131k hizmetlerinin kar\u015f\u0131 kar\u015f\u0131ya oldu\u011fu en b\u00fcy\u00fck zorluklar sizce nelerdir?<\/h2>\r\n<p><img class=\"alignleft size-medium wp-image-90857\" src=\"https:\/\/www.alj.com\/app\/uploads\/2021\/08\/Prof-James-J.-Collins-test-tube-192x300.jpg\" alt=\"Prof James J. Collins\" width=\"192\" height=\"300\" \/>\u00c7o\u011fu insan, k\u00fcresel sa\u011fl\u0131k sorunlar\u0131n\u0131n yaln\u0131zca bula\u015f\u0131c\u0131 hastal\u0131klar etraf\u0131nda oldu\u011funu d\u00fc\u015f\u00fcn\u00fcr. Kendi alan\u0131mda, COVID-19 k\u00fcresel salg\u0131n\u0131n\u0131n bir sonucu olarak bula\u015f\u0131c\u0131 hastal\u0131klar, \u00f6zellikle antibiyotikler ve giderek artan oranda antiviraller \u00fczerinde \u00e7al\u0131\u015f\u0131yoruz. Ancak yeterince \u00fczerinde durulmayan bir husus da geli\u015fmekte olan \u00fclkelerdeki kanser ve dejeneratif sinir rahats\u0131zl\u0131klar\u0131 dahil olmak \u00fczere bula\u015f\u0131c\u0131 olmayan hastal\u0131klarla ilgili b\u00fcy\u00fck zorluklarla kar\u015f\u0131la\u015fmalar\u0131.<\/p>\r\n<p>Bu nedenle, en b\u00fcy\u00fck zorluk hem bula\u015f\u0131c\u0131 hem de bula\u015f\u0131c\u0131 olmayan hastal\u0131klarda g\u00f6rd\u00fc\u011f\u00fcm\u00fcz harika geli\u015fmeleri herkes i\u00e7in uygun fiyatl\u0131 ve eri\u015filebilir hale getirmek.<\/p>\r\n<p>Geleneksel olarak, k\u00fcresel kamu sa\u011fl\u0131\u011f\u0131 ile ilgili \u00e7abalar\u0131n \u00e7o\u011fu kar amac\u0131 g\u00fctmeyen bir alanda olmu\u015ftur. Abdul Latif Jameel Health\u2019in misyonlar\u0131ndan biri, bunun <em>k\u00e2r ama\u00e7l\u0131<\/em> bir perspektiften nas\u0131l elde edilebilece\u011fini g\u00f6rmek ve anlaml\u0131 bir de\u011fi\u015fim sa\u011flamak i\u00e7in piyasa g\u00fc\u00e7lerinden ve piyasa te\u015fviklerinden yararlanmakt\u0131r.<\/p>\r\n<p>Ki\u015fisel ilgi alanlar\u0131m\u0131n \u00e7o\u011fu bula\u015f\u0131c\u0131 hastal\u0131klara odaklan\u0131yor; ancak yapay zeka ve sentetik biyolojiden gelen \u00e7e\u015fitli ara\u00e7lar\u0131n di\u011fer karma\u015f\u0131k hastal\u0131klar\u0131n nas\u0131l \u00fcstesinden gelebilece\u011fini ve d\u00fcnya genelinde daha geni\u015f sa\u011fl\u0131k sorunlar\u0131n\u0131 ele almak i\u00e7in nas\u0131l tahsis edilebilece\u011fini art\u0131k daha fazla ara\u015ft\u0131r\u0131yoruz.<\/p>\r\n<h2>Yapay zeka, b\u00fcy\u00fck veri ve makine \u00f6\u011frenimi gibi teknolojilerin sa\u011fl\u0131k hizmetlerinde yenilikleri nas\u0131l geli\u015ftirdi\u011fine dair baz\u0131 \u00f6rnekler verebilir misiniz?<\/h2>\r\n\r\n[caption id=\"attachment_57747\" align=\"alignright\" width=\"300\"]<img class=\"size-medium wp-image-57747\" src=\"https:\/\/www.alj.com\/app\/uploads\/2020\/02\/halicin-antibiotics-300x300.jpg\" alt=\"Halicin\" width=\"300\" height=\"300\" \/> Halicin\u2019in (\u00fcstte) E. coli\u2019deki antibiyotik direncini \u00f6nledi\u011fini ve siprofloksasin\u2019de (altta) bu etkinin olmad\u0131\u011f\u0131n\u0131 g\u00f6steren, g\u00fcn\u00fcm\u00fczde herkes\u00e7e bilinen \u00fcnl\u00fc MIT g\u00f6r\u00fcnt\u00fcs\u00fc.<br \/>\r\nFoto\u011fraf Sahibi \u00a9 MIT\u2019deki Collins Lab\u2019in izniyle[\/caption]\r\n\r\n<p>E\u011fer \u00f6ncelikle antibiyotikleri ele alacak olursak; antibiyotik direnci krizinin \u00fcstesinden gelmek i\u00e7in yapay zekan\u0131n g\u00fcc\u00fcnden yararlan\u0131p yararlanamayaca\u011f\u0131m\u0131z\u0131 g\u00f6rmek \u00fczere, Jameel Clinic\u2019in bir par\u00e7as\u0131 olarak Regina Barzilay, Tommi Jaakkola ve ben bir i\u015f birli\u011fi yapt\u0131k. \u00c7oklu ilaca diren\u00e7li, geni\u015f ila\u00e7 diren\u00e7li ve pan diren\u00e7li patojenler de dahil olmak \u00fczere geni\u015f bir yelpazede patojenlere kar\u015f\u0131 \u00e7ok etkili olan <a href=\"https:\/\/www.alj.com\/en\/news\/j-clinic-discovers-powerful-new-antibiotic-using-ai-technology\/\">Halicin<\/a> adl\u0131 g\u00fc\u00e7l\u00fc yeni bir antibiyotik ke\u015ffetmemize yard\u0131mc\u0131 olmas\u0131 i\u00e7in bir yapay zeka modelini e\u011fitti\u011fimiz bir pilot \u00e7abas\u0131n\u0131 ilerletmeyi ba\u015fard\u0131k.<\/p>\r\n<p>Bu modeli, yaln\u0131zca birka\u00e7 g\u00fcn i\u00e7inde 1,5 milyar molek\u00fclden olu\u015fan devasa bir k\u00fct\u00fcphaneye uygulayabildik ve \u00e7ok say\u0131da yeni antibiyotik aday\u0131 belirledik.<\/p>\r\n<p>Halicin\u2019de yapt\u0131\u011f\u0131m\u0131z gibi, yeni bir antibiyotik s\u0131n\u0131f\u0131 tasarlamak ve ke\u015ffetmek i\u00e7in yapay zekay\u0131 kullanmak amac\u0131yla Jameel Clinic arac\u0131l\u0131\u011f\u0131yla MIT\u2019te Antibiyotik Yapay Zekas\u0131 projesini ba\u015flatt\u0131k.<\/p>\r\n<p>Sentetik biyoloji taraf\u0131nda ise tasarlanm\u0131\u015f sentetik gen devrelerini h\u00fccresiz ekstraktlarla birlikte kullanabilece\u011finizi daha \u00f6nce belirlemi\u015ftik. H\u00fccresiz sistemler s\u00f6z konusu oldu\u011funda, canl\u0131 bir h\u00fccreyi a\u00e7abilir ve \u201cmakineleri\u201d o h\u00fccreden \u00e7\u0131karabilirsiniz. Kaydetti\u011fimiz ilerleme, ucuz ka\u011f\u0131t tabanl\u0131 tan\u0131lar olu\u015fturmak i\u00e7in bu h\u00fccresiz ekstrakt\u0131 sentetik biyoloji gen devreleriyle birlikte ka\u011f\u0131t \u00fczerinde dondurarak dondurabilece\u011finizi g\u00f6stermek oldu.<\/p>\r\n<p>Belki de en \u00e7arp\u0131c\u0131 \u015fey, COVID-19 k\u00fcresel salg\u0131n\u0131n\u0131n ortas\u0131nda ve Jameel Clinic\u2019in himayesi alt\u0131nda, SARS-CoV-2\u2019ye y\u00fcksek duyarl\u0131l\u0131k ve y\u00fcksek \u00f6zg\u00fcll\u00fck sahibi, nispeten birka\u00e7 dakikada bir sonu\u00e7 verebilecek COVID-19 y\u00fcz maskesi tan\u0131s\u0131n\u0131 olu\u015fturmak i\u00e7in sentetik biyoloji kullanabilece\u011fimizi k\u0131smen g\u00f6stermeyi ba\u015farm\u0131\u015f olmam\u0131zd\u0131. \u00d6zetle bu, COVID-19 ge\u00e7irip ge\u00e7irmedi\u011fimizi s\u00f6yleyebilecek bir y\u00fcz maskesi.<\/p>\r\n<h2>Bu geli\u015fmeler sat\u0131\u015fa sunulmaya ne kadar yak\u0131n?<\/h2>\r\n<p>Halicin\u2019in toksisitesini ke\u015ffetmek, toksisiteyi gidermek i\u00e7in analoglar geli\u015ftirmek ve ila\u00e7 benzeri \u00f6zelliklerinin ek y\u00f6nlerini ara\u015ft\u0131rmak amac\u0131yla potansiyel bir klinik ara\u015ft\u0131rmaya do\u011fru ilerliyoruz.<\/p>\r\n<p>Ka\u011f\u0131t tabanl\u0131 tan\u0131 ile ilgili olarak <a href=\"https:\/\/sherlock.bio\/\">sentetik biyoloji platformumuza dayanan FDA onayl\u0131 bir COVID-19 tan\u0131s\u0131 geli\u015ftiren<\/a> MIT\u2019teki <a href=\"https:\/\/sherlock.bio\/sherlock-biosciences-receives-fda-emergency-use-authorization-for-crispr-sars-cov-2-rapid-diagnostic\/\">Sherlock Biosciences<\/a>\u2019tan bir yan \u00fcr\u00fcne sahibiz. Bu, \u00e7ok say\u0131da global tan\u0131 firmas\u0131n\u0131n yan\u0131 s\u0131ra \u015fu anda Nepal \u00fclkesinin ulusal testlerinde benimsenmi\u015ftir. Sherlock Biosciences ve ortaklar\u0131, art\u0131k d\u00fcnya genelinde her ay 10 milyon COVID-19 tan\u0131 testi ger\u00e7ekle\u015ftirmek i\u00e7in teknolojimizi kullanmaya do\u011fru h\u0131zl\u0131 ad\u0131mlarla ilerliyorlar.<\/p>\r\n<p>Tan\u0131 y\u00fcz maskesi hala akademik a\u015famada. Hen\u00fcz sat\u0131\u015fa sunulmad\u0131 ancak bunu MIT ve Wyss Institute\u2019taki bir laboratuvar demosundan mahallenizdeki eczaneden alabilece\u011finiz bir \u00fcr\u00fcne nas\u0131l ta\u015f\u0131yabilece\u011fimizi ke\u015ffetmek, ilgin\u00e7 bir f\u0131rsat olacak.<\/p>\r\n<h2>Bu gibi yeniliklerin t\u00fcm d\u00fcnyaya yay\u0131lmas\u0131n\u0131 ve sadece zengin uluslar\u0131n faydaland\u0131\u011f\u0131 bir sa\u011fl\u0131k hizmeti olmamas\u0131n\u0131 sa\u011flamak ne kadar \u00f6nemli?<\/h2>\r\n<p>Teknolojilerimizin herkese a\u00e7\u0131k olmas\u0131n\u0131 sa\u011flamaya \u00e7al\u0131\u015fmak, profes\u00f6r ve giri\u015fimci olarak misyonumun \u00f6nemli bir par\u00e7as\u0131. \u00d6zellikle ABD\u2019de, \u00e7o\u011fu zaman etkiden daha fazla k\u00e2r elde etmek isteyen \u015firketler g\u00f6r\u00fcyoruz. Benim i\u00e7in etki, k\u00e2rdan \u00e7ok daha \u00f6nemlidir. \u00dcr\u00fcnden milyonlarca dolar kazanmak yerine milyonlarca ki\u015fiye fayda sa\u011flayan bir \u00fcr\u00fcn g\u00f6rmeyi \u00e7ok daha fazla tercih ederim.<\/p>\r\n<h2>COVID-19 k\u00fcresel salg\u0131n\u0131 insanlar\u0131 bu konuda daha fazla d\u00fc\u015f\u00fcnmeye te\u015fvik etti mi?<\/h2>\r\n<p>Evet ama olmas\u0131 gerekti\u011fi kadar de\u011fil. Ne yaz\u0131k ki h\u0131rs, bu d\u00fcnyada \u00e7ok etkili bir g\u00fc\u00e7.<\/p>\r\n<p><img class=\"alignright size-full wp-image-90850\" src=\"https:\/\/www.alj.com\/app\/uploads\/2021\/08\/Logo.jpg\" alt=\"221B Foundation Logo\" width=\"195\" height=\"88\" \/>Bu nedenle, Sherlock Biosciences arac\u0131l\u0131\u011f\u0131yla, ad\u0131n\u0131 Sherlock Holmes\u2019\u00fcn Londra\u2019daki kurgusal adresinden alan <a href=\"https:\/\/221bfoundation.org\/\">221b Vakf\u0131 <\/a>isimli bir vak\u0131f kurduk.<\/p>\r\n<p>COVID-19 \u00fcr\u00fcn\u00fcm\u00fczden elde etti\u011fimiz t\u00fcm k\u00e2rlar\u0131 vak\u0131flara ba\u011f\u0131\u015flaman\u0131n yan\u0131 s\u0131ra, k\u00e2rlar\u0131n vak\u0131flara geri d\u00f6nmesi gerekti\u011fi anlay\u0131\u015f\u0131yla COVID-19 tan\u0131lar\u0131n\u0131 geli\u015ftirmek isteyen herhangi bir kurulu\u015fa CRISPR tan\u0131lar\u0131 ile ilgili t\u00fcm IP\u2019mizi sunmay\u0131 taahh\u00fct ettik.<\/p>\r\n<p>Bu k\u00e2rlar daha sonra, yeterince temsil edilemeyen az\u0131nl\u0131klara y\u00f6nelik STEM (Bilim, Teknoloji, M\u00fchendislik ve Matematik) \u00e7abalar\u0131n\u0131 geli\u015ftirmeye, daha fazla gen\u00e7 insan\u0131 STEM alanlar\u0131nda \u00e7al\u0131\u015fmaya, teknolojileri geli\u015ftirmeye ve k\u00fcresel sa\u011fl\u0131k sorunlar\u0131n\u0131 ele almaya te\u015fvik etmeye y\u00f6nelik \u00e7abalara adanmaktad\u0131r.<\/p>\r\n<h2>Jameel Clinic bir b\u00fct\u00fcn olarak bu sorunlar\u0131n baz\u0131lar\u0131n\u0131n \u00fcstesinden gelmeye nas\u0131l yard\u0131mc\u0131 oluyor?<\/h2>\r\n\r\n[caption id=\"attachment_53569\" align=\"alignright\" width=\"300\"]<img class=\"size-medium wp-image-53569\" src=\"https:\/\/www.alj.com\/app\/uploads\/2019\/11\/Hassan-Jameel-JClinic-300x200.jpg\" alt=\"Jameel Clinic\" width=\"300\" height=\"200\" \/> 2018 y\u0131l\u0131nda d\u00fczenlenen MIT Jameel Clinic kurulu\u015f t\u00f6reninde Hassan Jameel (solda), MIT Rekt\u00f6r\u00fc L. Rafael Reif (ortada) ve Fady Jameel (sa\u011fda).[\/caption]\r\n\r\n<p>Jameel Clinic yakla\u015f\u0131k \u00fc\u00e7 y\u0131l \u00f6nce (2018) kuruldu ve o zamandan beri bir dizi heyecan verici programla geli\u015fti.<\/p>\r\n<p>Pandeminin ortas\u0131nda bu Klinik, AI Cures adl\u0131 bir program ba\u015flatt\u0131. Bu program, yapay zekay\u0131 SARS-CoV-2 de dahil olmak \u00fczere geli\u015fmekte olan patojenlerle m\u00fccadele ederken kullanmay\u0131 ama\u00e7l\u0131yor. Bu giri\u015fimin bir par\u00e7as\u0131 olarak; d\u00fcnyan\u0131n d\u00f6rt bir yan\u0131ndaki ara\u015ft\u0131rmac\u0131lar taraf\u0131ndan eri\u015filebilir hale getirilen bir dizi ilgin\u00e7 veri setini bir araya getirebildik.<\/p>\r\n<p>Regina Barzilay ve Tommi Jaakkola ve birka\u00e7 mezun \u00f6\u011frencisi ile birlikte \u00e7al\u0131\u015farak, \u00f6rne\u011fin COVID-19\u2019a neden olan bir patojen olan SARS-CoV-2\u2019yi tedavi etmek i\u00e7in etkili kombinasyonlar geli\u015ftirmek \u00fczere yapay zekay\u0131 da kullanabildik.<\/p>\r\n<h2>Yapay zeka, b\u00fcy\u00fck veri ve makine \u00f6\u011freniminin, sa\u011fl\u0131k sekt\u00f6r\u00fcndeki inovasyonlarda ezber bozan etkenler olmalar\u0131n\u0131 sa\u011flayan nedir?<\/h2>\r\n<p>Yapay zeka ve b\u00fcy\u00fck verinin en \u00f6nemli \u00f6zelli\u011fi; bu kaynaklar\u0131n, biyoloji ve kimyan\u0131n karma\u015f\u0131kl\u0131\u011f\u0131n\u0131 tek ba\u015f\u0131na beynimizin ba\u015farabilece\u011fi her \u015feyin \u00e7ok \u00f6tesinde bir \u00f6l\u00e7ekte ele almam\u0131z\u0131 sa\u011flamas\u0131d\u0131r.<\/p>\r\n\r\n[caption id=\"attachment_87909\" align=\"alignleft\" width=\"300\"]<img class=\"size-medium wp-image-87909\" src=\"https:\/\/www.alj.com\/app\/uploads\/2021\/04\/James-J-Collins-T-300x162.jpg\" alt=\"James J Collins\" width=\"300\" height=\"162\" \/> James J Collins[\/caption]\r\n\r\n<p>En basit canl\u0131 h\u00fccreleri olan bakteriler bile gezegenimizde tasarlad\u0131\u011f\u0131m\u0131z en karma\u015f\u0131k makineden \u00e7ok daha karma\u015f\u0131kt\u0131r. Bu t\u00fcr bir canl\u0131 sistemin milyarlarca y\u0131l boyunca nas\u0131l geli\u015fti\u011fini kapsaml\u0131 bir \u015fekilde anlamak imkans\u0131zd\u0131r.<\/p>\r\n<p>Benzer \u015fekilde, geli\u015ftirdi\u011fimiz bir ilac\u0131n canl\u0131 bir h\u00fccre veya h\u00fccre k\u00fcmesinin karma\u015f\u0131k biyolojisini nas\u0131l etkileyebilece\u011fini anlamak inan\u0131lmaz derecede zordur. B\u00fcy\u00fck veri ve yapay zeka bunu yapmam\u0131z\u0131 sa\u011flar. Bu teknolojileri, ya\u015fayan bir h\u00fccrenin biyolojisini daha \u00f6nce yapamad\u0131\u011f\u0131m\u0131z bir \u00f6l\u00e7ekte sorgulamak i\u00e7in kullanabiliriz. Bu, canl\u0131 bir h\u00fccredeki t\u00fcm bu harika bile\u015fenlerin sa\u011fl\u0131kl\u0131 bir durum yaratmak i\u00e7in nas\u0131l etkile\u015fimde bulunduklar\u0131 ve bir hastal\u0131k durumu olu\u015fturmak i\u00e7in etkile\u015fimlerinin nas\u0131l bozulabilece\u011fi hakk\u0131nda daha iyi i\u00e7g\u00f6r\u00fcler olu\u015fturmak amac\u0131yla molek\u00fcller aras\u0131ndaki etkile\u015fimi anlamam\u0131z\u0131 sa\u011flar. B\u00f6ylece hastal\u0131kl\u0131 veya yaral\u0131 bir durumu d\u00fczeltmek veya iyile\u015ftirmek i\u00e7in potansiyel olarak nas\u0131l m\u00fcdahale edebilece\u011fimizi belirleyebiliriz.<\/p>\r\n<h2>Bu teknolojilerin potansiyeli hen\u00fcz tam olarak anla\u015f\u0131ld\u0131 m\u0131?<\/h2>\r\n<p>Kesinlikle hay\u0131r. Sa\u011fl\u0131k hizmetlerindeki zorluklar i\u00e7in yapay zekay\u0131 kullanma konusunda h\u00e2l\u00e2 yolun daha \u00e7ok ba\u015f\u0131nday\u0131z. Yapay zeka ve b\u00fcy\u00fck verilerin bilgi d\u00fcnyas\u0131nda ve internette b\u00fcy\u00fck bir etkisi oldu\u011funu g\u00f6rd\u00fck ancak biyoloji ve t\u0131p alanlar\u0131nda b\u00fcy\u00fck veriler hala emekleme \u00e7a\u011f\u0131nda. San\u0131r\u0131m \u00f6n\u00fcm\u00fczdeki on y\u0131l i\u00e7inde giderek daha fazla veri toplan\u0131p kullan\u0131ma sunulduk\u00e7a geli\u015fmelerin artt\u0131\u011f\u0131n\u0131 g\u00f6rece\u011fiz. Jameel Clinic\u2019teki misyonumuzdan biri, yeni nesil sa\u011fl\u0131k ara\u015ft\u0131rmac\u0131lar\u0131n\u0131 \u00e7ok disiplinli olmalar\u0131 i\u00e7in e\u011fitmek. B\u00f6ylece, hastalar i\u00e7in \u00f6nemli olan at\u0131l\u0131mlar\u0131 yapmak \u00fczere teknoloji, bilim ve t\u0131p aray\u00fcz\u00fcnde \u00e7al\u0131\u015fmalar\u0131n\u0131 sa\u011flayan hem yapay zeka\/makine \u00f6\u011frenimi hem de biyoloji ve kimya alanlar\u0131nda uzmanl\u0131k sahibi olacaklar.<\/p>\r\n<h2>\u0130leriye bakt\u0131\u011f\u0131n\u0131zda, k\u00fcresel sa\u011fl\u0131k hizmetlerinin orta ve uzun vadeli gelece\u011finin neye benzeyece\u011fini d\u00fc\u015f\u00fcn\u00fcyorsunuz?<\/h2>\r\n<p>Bence k\u00fcresel salg\u0131n\u0131n birka\u00e7 avantaj\u0131ndan biri, gen\u00e7ler aras\u0131nda bula\u015f\u0131c\u0131 hastal\u0131klar\u0131n dikkat \u00e7ekmeye de\u011fer ciddi bir konu oldu\u011funa ili\u015fkin fark\u0131ndal\u0131\u011f\u0131 art\u0131rmas\u0131d\u0131r. Bu nedenle, enfeksiyonlar\u0131 tespit etme, tedavi etme ve \u00f6nleme bilgimizi ve yeteneklerimizi kesinlikle geli\u015ftirecek olan bula\u015f\u0131c\u0131 hastal\u0131klar ve k\u00fcresel sa\u011fl\u0131k alan\u0131na daha fazla gen\u00e7 yetenek gelece\u011fini d\u00fc\u015f\u00fcn\u00fcyorum.<\/p>\r\n<p>\u0130leriye bakt\u0131\u011f\u0131m\u0131zda, biyot\u0131pta kesinlikle \u00e7arp\u0131c\u0131 ve etkileyici de\u011fi\u015fiklikler ve geli\u015fmeler g\u00f6rece\u011fiz. B\u00fcy\u00fck verilerin, yapay zeka ve sentetik biyoloji dahil olmak \u00fczere geli\u015fmi\u015f teknolojilerin g\u00fcn ge\u00e7tik\u00e7e artan etkilerini, ekonomik olarak verimli ve herkes i\u00e7in uygun fiyatl\u0131 bir \u015fekilde d\u00fcnya genelinde hastal\u0131klar\u0131 daha iyi te\u015fhis etmemizi, tedavi etmemizi ve hastal\u0131klar\u0131 \u00f6nlememizi sa\u011flayan \u00e7abalar\u0131 ilerletirken g\u00f6rece\u011fiz.<\/p>"],"_content":[""],"_ame_cpe_post_policy":["{\"accessProtection\":{\"active\":\"replace\"}}"],"_edit_last":["22"],"_wpml_media_duplicate":["1"],"_wpml_media_featured":["1"],"_yoast_wpseo_content_score":["30"],"_yoast_wpseo_estimated-reading-time-minutes":["11"]},"_links":{"self":[{"href":"https:\/\/cms.alj3.clients.lemonhq.io\/tr\/wp-json\/wp\/v2\/perspectives\/14866","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cms.alj3.clients.lemonhq.io\/tr\/wp-json\/wp\/v2\/perspectives"}],"about":[{"href":"https:\/\/cms.alj3.clients.lemonhq.io\/tr\/wp-json\/wp\/v2\/types\/perspectives"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cms.alj3.clients.lemonhq.io\/tr\/wp-json\/wp\/v2\/media\/14852"}],"wp:attachment":[{"href":"https:\/\/cms.alj3.clients.lemonhq.io\/tr\/wp-json\/wp\/v2\/media?parent=14866"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}