{"id":15673,"date":"2022-08-03T00:00:00","date_gmt":"2022-08-03T00:00:00","guid":{"rendered":"https:\/\/cms.alj3.clients.lemonhq.io\/perspectives\/faconner-un-nouveau-modele-de-traitement-contre-le-cancer\/"},"modified":"2026-05-12T11:28:25","modified_gmt":"2026-05-12T11:28:25","slug":"faconner-un-nouveau-modele-de-traitement-contre-le-cancer","status":"publish","type":"perspectives","link":"https:\/\/cms.alj3.clients.lemonhq.io\/fr\/perspectives\/faconner-un-nouveau-modele-de-traitement-contre-le-cancer\/","title":{"rendered":"Fa\u00e7onner un nouveau mod\u00e8le de traitement contre le cancer"},"content":{"rendered":"

Republished from Abdul Latif Jameel Health Insights here<\/a>.<\/em><\/p>\n

A Q&A with Professor R Charles Coombes, newly appointed special scientific advisor to Abdul Latif Jameel Health<\/h4>\n

The latest special scientific advisor to join the Advisory Board of <\/em>Abdul Latif Jameel Health<\/em><\/a> is <\/em>Professor Charles Coombes<\/em><\/a>, a renowned world-leading authority on cancer, with a particular focus on breast cancer. \u00a0We spoke to Professor Coombes about his research, his new role at Abdul Latif Jameel Health, and his vision for the future of global healthcare.<\/em><\/p>\n

As part of its mission to accelerate access to modern quality healthcare around the world, Abdul Latif Jameel Health is continually looking to build partnerships with the leading innovators, organizations, and researchers in the global healthcare industry.<\/p>\n

\"\"

Professor Charles Coombes PhD MBBS FRCP MD FMedSci<\/p><\/div>\n

\"\"Professor R Charles Coombes is Professor of Medical Oncology, Imperial College London<\/a>, and Honorary Consultant Medical Oncologist at Imperial College Healthcare Trust<\/a>.<\/p>\n

He is also Chairman of the International Collaborative Cancer Group<\/a> \u2013 a multinational trial center (based at Imperial College London) focusing on phase II and III studies in breast cancer, among other senior roles in oncology.<\/p>\n

\"\"A keen advocate of a cross-disciplinary approach to cancer research, Professor Coombes helped to establish the Convergence Science Centre<\/a> at Imperial College in 2020.<\/p>\n

He also runs a translational laboratory which focuses on detection of micro-metastatic disease and application to the treatment of breast cancer.<\/p>\n

Could you provide a brief overview of your current work?<\/h2>\n

CC: <\/strong>One of the most important initiatives I\u2019m involved with at the moment is the Convergence Science Centre, which is a strategic partnership between Imperial College London<\/a> and The Institute of Cancer Research, London<\/a>, that was initiated around seven years ago.<\/p>\n

\"\"The aim of the program is to bring together the science expertise of Imperial College across a whole range of disciplines to help people with cancer.<\/p>\n

The most common sciences used in cancer detection and treatment are molecular and cell biology and drug discovery, but it\u2019s now widely recognized that this isn\u2019t enough.<\/p>\n

To truly make headway with this complex disease, you need to leverage the latest expertise from other scientific fields, too, such as bioengineering, mathematics, physics, population sciences, computing sciences, and so forth, which have traditionally been neglected in cancer research.<\/p>\n

This work was built on the fact that I\u2019ve spent half of my career at The Institute of Cancer Research and The Royal Marsden Hospital in London, and half my career at Imperial College.\u00a0 It seemed logical \u00a0that if we could bring together these two great institutions, both of which, combined, probably rank among the top in the UK \u2013 if not the world \u2013 in terms of cancer expertise, it could help us solve this problem.<\/p>\n

Could you explain how the Convergence Science Centre works?<\/h2>\n

CC: <\/strong>It\u2019s a sad fact that although cancer affects nearly half of us, in the West at least, it\u2019s not easy to predict which person is going to develop what cancer.\u00a0 And if cancer does develop, it\u2019s not easy to predict how the cancer is going to evolve in the human body. \u00a0This uncertainty means we can\u2019t harness new molecular treatments and diagnostic technology in the best way.\u00a0 We now have blood tests and sputum tests that can detect cancer at an extremely early stage, and blood tests that can tell you how the cancer is evolving in the patient.\u00a0 But until we have ways of enriching these technologies, we cannot refine them to be available to everyone in the world.<\/p>\n

The Convergence Science Centre helps to bring multiple scientific disciplines together to try and bridge some of these gaps in crucial areas, such as the extremely complex mathematics around genetics and DNA.<\/p>\n

What are the benefits of this approach?<\/h2>\n

CC: <\/strong>Cancer treatment in the West is based on a set of rather toxic treatments such as radiotherapy \u00a0and cytotoxic chemotherapy, and so forth.\u00a0 These are ill-defined and non-targeted technologies that as well as combating cancer, are also damaging to normal cells.\u00a0 For the \u2018global south\u2019, the aim is to sidestep these, potentially rather harmful, treatments and go straight to the latest modern diagnostic and therapeutic approaches.\u00a0 For example, artificial intelligence can define which patients need to be screened, and the type of cancer and the evolution of the cancer can all be diagnosed by\u00a0 blood tests.\u00a0 You don\u2019t need complex radiotherapy systems and large healthcare infrastructures.\u00a0 What we will need in the future are usable diagnostic technologies and targeted treatments that will enable us to avoid the sorts of damaging treatments that people have had to undergo to have their cancer treated over the last 50 years.<\/p>\n

The combination of easy diagnostics and then targeted treatment following surgery is the answer to improving the survival rate of cancer in the global south.<\/p>\n

When did you first become aware of Abdul Latif Jameel Health?<\/h2>\n

CC: <\/strong>It is a name I\u2019ve known for a while \u2013 an organization that I knew was interested in improving access to quality healthcare in emerging markets in the Middle East, Africa and Asia, which is an issue I care deeply about.\u00a0 I regularly attend conferences and I\u2019m invited to give lectures in locations across the world, particularly the MENA region, and Abdul Latif Jameel is a name that often comes up.\u00a0 So, when the opportunity arose to get involved more directly, I was keen to learn more.<\/p>\n

In your role as a special scientific advisor, what do you hope to bring to the organization?<\/h2>\n

CC: <\/strong>I\u2019m a cancer clinician and cancer scientist.\u00a0 There is a big gap between what people discover in laboratories and how it\u2019s brought into clinical use and then applied to patients.\u00a0 This gap is often ignored, because scientists are always moving on to the next thing, the next stage in their research, to constantly refine and improve what they\u2019ve done.<\/p>\n

It needs somebody like me at Imperial College to take what they\u2019ve developed and say \u201cI know you\u2019re still working on this, but what you\u2019ve got so far looks pretty good.\u00a0 There\u2019s nothing like it out there, so let\u2019s see if we can use it to help people.\u201d<\/em>\u00a0 It\u2019s what I\u2019ve been doing all my career.\u00a0 I\u2019ve been involved in developing new drugs for cancer, new diagnostic tests, mainly for breast cancer, for 40 years, and that\u2019s what I\u2019m aiming to continue doing through my role at Abdul Latif Jameel Health.<\/p>\n

Abdul Latif Jameel Health has a particular focus on improving access to healthcare in the global south. \u00a0Is this important to you?<\/h2>\n

CC: <\/strong>Yes, absolutely.\u00a0 It\u2019s an issue I\u2019m passionate about.\u00a0 For example, I\u2019ve lectured in Nigeria where there was a single cancer center with functioning equipment for the entire country of 160 million people.\u00a0 I\u2019ve been to many countries in the region where there is huge poverty, inequality, and a lack of diagnostic capability.<\/p>\n

As well as financial hurdles to overcome, there are often cultural ones, too, in terms of educating people about cancer and helping them to understand that it\u2019s not something to be ashamed of or embarrassed about.<\/p>\n

What do you see as the biggest challenges for cancer research and treatment?<\/h2>\n

CC: <\/strong>I think education is the most important thing.\u00a0 You could invest any amount of money, but without education it is only going to have a limited impact.\u00a0 The first thing to do is to educate people about illnesses and what can be done about them.\u00a0 The next priority is screening people at risk and introducing some sort of clear pathway for them to get help easily.\u00a0 To a certain degree, a lot of this could be done remotely using modern technology.\u00a0 The idea of people having to travel hundreds of miles and wait for hours in a hospital in the hope of seeing a doctor doesn\u2019t work in the modern world.<\/p>\n

One thing the COVID-19 pandemic taught us is that communication across the world is much easier than we thought.\u00a0 We should be using this to our advantage to make healthcare much more accessible in those markets that most need it.<\/p>\n

How could technologies like artificial intelligence and big data help to improve this picture?<\/h2>\n

CC: <\/strong>These kinds of technologies are hugely important to the fight against cancer, and increasingly so. Artificial intelligence (AI) is sometimes spoken of as if it\u2019s some sort of separate discipline, but it\u2019s not.\u00a0 It\u2019s already integrated within the work that \u00a0I and many cancer researchers do.<\/p>\n

Half the scientists we employ now are specialists in AI. \u00a0Not just talented mathematicians, but people who also understand genetics, biology, cancer, who can bridge these divides and bring that knowledge together.\u00a0 This is modern cancer research, and this is what the Convergence Science Centre aims to do.<\/p>\n

\"\"

Photo Credit \u00a9 Cancer Research UK Imperial Centre<\/p><\/div>\n

A single cell is probably more complex than all the computers currently available throughout the world. \u00a0Within a tiny teaspoon of blood from a cancer patient, there are more than a million fragments of DNA and RNA, all of which give information about the type of cancer they\u2019ve got and how to treat that cancer.\u00a0 But decoding that information and making it sense of it all is impossible without AI.\u00a0 Working out which sub-populations have a greater propensity to develop cancer and therefore more likely to benefit from screening is another critical area where AI is essential.\u00a0 \u00a0And then of course, there are the families with a history of cancer where AI is vital for helping us to understand the genetics of cancer predisposition.<\/p>\n

Another area where AI is essential is in terms of chemistry and target identification.\u00a0 When, for example, a blood test shows there is cancer present and that it is growing and dividing by a certain type of factor, to build a drug to inhibit that you need to know the structure of the protein that the drug is supposed to bind to, to inhibit the cancer proliferation in that particular patient.\u00a0 It\u2019s extraordinarily complex and relies on AI at virtually every stage in the journey to discover a new drug.<\/p>\n

How has the pandemic changed the narrative around global healthcare?<\/h2>\n

CC: <\/strong>I think it has changed it in two main ways.\u00a0 First, it has shown people that science can have a global impact.\u00a0 There\u2019s been a certain amount of cynicism about modern science among commentators before the pandemic, around climate change for example.\u00a0 The pandemic has shown the massively positive impact that science can have and how it can improve health outcomes for people across the globe.<\/p>\n

The second big change is that the pandemic has highlighted the inequality of healthcare between different regions of the world.\u00a0 The proportion of people in the global south who have been vaccinated is still incredibly low, for example.<\/p>\n

Within the field of cancer specifically, there is growing understanding that, in the same way that viruses evolve and change their genetics to overcome treatments, cancer does too.\u00a0 \u00a0People have become used to the idea of sequencing viruses and the same thing is true in cancer.\u00a0 You need to monitor the cancer in the patient to predict what treatments you\u2019re going to give the patient.\u00a0 That\u2019s very similar to the development of vaccines for mutated viruses.<\/p>\n

How do you hope Abdul Latif Jameel Health can help to improve this picture and address some of these challenges?<\/h2>\n

CC: <\/strong>I believe Abdul Latif Jameel Health has a fairly unique role in that it is interested in early diagnosis, and it seeks to bring the latest healthcare advances to underserved markets in the global south.\u00a0 The Butterfly iQ+ handheld ultrasound device<\/a>, for example, is an example of a technology that could make a huge difference in many markets though earlier diagnosis.<\/p>\n

\"Butterfly

The Butterfly IQ+ hand-held, whole-body ultrasound probe in action (Photo Credit \u00a9 Butterfly Network Inc.)<\/p><\/div>\n

Abdul Latif Jameel\u2019s strong legacy in the region, its knowledge, understanding and existing partnerships, can also be a great advantage in getting these technologies out into the market and overcoming some of the barriers \u2013 often cultural and practical issues as much as financial ones.<\/p>\n

Looking ahead, how optimistic are you for the future of cancer research and cancer treatment?<\/h2>\n

CC: <\/strong>I\u2019m biased, because in my area of breast cancer I\u2019ve seen the cure rate improving quite dramatically throughout my career, so in that sense I\u2019m very optimistic.\u00a0 Of course, there are still big discrepancies in breast cancer rates across the globe, but overall, I\u2019m hopeful that in 10 years we will have significantly improved the cure rate.<\/p>\n

Other cancers, like lung cancer, pancreatic cancer, brain cancer, stomach cancer for example, are very difficult to treat, partly because they are diagnosed too late.\u00a0 This is where some of these technologies around testing, screening and early diagnosis are vital.\u00a0 These could change the face of cancer treatment, particularly in the global south, if we can apply them effectively.<\/p>\n

So, I\u2019m optimistic, but it needs to be done on almost an \u2018industrial\u2019 scale rather than the piecemeal methods that have been used up to now.<\/p>\n","protected":false},"featured_media":15663,"menu_order":0,"template":"","class_list":["post-15673","perspectives","type-perspectives","status-publish","has-post-thumbnail","hentry"],"acf":[],"yoast_head":"\nFa\u00e7onner un nouveau mod\u00e8le de traitement contre le cancer - Abdul Latif Jameel<\/title>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Fa\u00e7onner un nouveau mod\u00e8le de traitement contre le cancer - Abdul Latif Jameel\" \/>\n<meta property=\"og:description\" content=\"Republished from Abdul Latif Jameel Health Insights here. A Q&A with Professor R Charles Coombes, newly appointed special scientific advisor to Abdul Latif Jameel Health The latest special scientific advisor to join the Advisory Board of Abdul Latif Jameel Health is Professor Charles Coombes, a renowned world-leading authority on cancer, with a particular focus on […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/cms.alj3.clients.lemonhq.io\/fr\/perspectives\/faconner-un-nouveau-modele-de-traitement-contre-le-cancer\/\" \/>\n<meta property=\"og:site_name\" content=\"Abdul Latif Jameel\" \/>\n<meta property=\"article:modified_time\" content=\"2026-05-12T11:28:25+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/media.alj3.clients.lemonhq.io\/wp-content\/uploads\/2024\/10\/Cancer-Cells-Illustration.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1546\" \/>\n\t<meta property=\"og:image:height\" content=\"1032\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Dur\u00e9e de lecture estim\u00e9e\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/cms.alj3.clients.lemonhq.io\/fr\/perspectives\/faconner-un-nouveau-modele-de-traitement-contre-le-cancer\/\",\"url\":\"https:\/\/cms.alj3.clients.lemonhq.io\/fr\/perspectives\/faconner-un-nouveau-modele-de-traitement-contre-le-cancer\/\",\"name\":\"Fa\u00e7onner un nouveau mod\u00e8le de traitement contre le cancer - Abdul Latif Jameel\",\"isPartOf\":{\"@id\":\"https:\/\/10.0.2.222\/en\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/cms.alj3.clients.lemonhq.io\/fr\/perspectives\/faconner-un-nouveau-modele-de-traitement-contre-le-cancer\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/cms.alj3.clients.lemonhq.io\/fr\/perspectives\/faconner-un-nouveau-modele-de-traitement-contre-le-cancer\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/media.alj3.clients.lemonhq.io\/wp-content\/uploads\/2024\/10\/Cancer-Cells-Illustration.jpg\",\"datePublished\":\"2022-08-03T00:00:00+00:00\",\"dateModified\":\"2026-05-12T11:28:25+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/cms.alj3.clients.lemonhq.io\/fr\/perspectives\/faconner-un-nouveau-modele-de-traitement-contre-le-cancer\/#breadcrumb\"},\"inLanguage\":\"fr-FR\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/cms.alj3.clients.lemonhq.io\/fr\/perspectives\/faconner-un-nouveau-modele-de-traitement-contre-le-cancer\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"fr-FR\",\"@id\":\"https:\/\/cms.alj3.clients.lemonhq.io\/fr\/perspectives\/faconner-un-nouveau-modele-de-traitement-contre-le-cancer\/#primaryimage\",\"url\":\"https:\/\/media.alj3.clients.lemonhq.io\/wp-content\/uploads\/2024\/10\/Cancer-Cells-Illustration.jpg\",\"contentUrl\":\"https:\/\/media.alj3.clients.lemonhq.io\/wp-content\/uploads\/2024\/10\/Cancer-Cells-Illustration.jpg\",\"width\":1546,\"height\":1032},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/cms.alj3.clients.lemonhq.io\/fr\/perspectives\/faconner-un-nouveau-modele-de-traitement-contre-le-cancer\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/10.0.2.222\/en\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Fa\u00e7onner un nouveau mod\u00e8le de traitement contre le cancer\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/10.0.2.222\/en\/#website\",\"url\":\"https:\/\/10.0.2.222\/en\/\",\"name\":\"Abdul Latif Jameel\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/10.0.2.222\/en\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"fr-FR\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Fa\u00e7onner un nouveau mod\u00e8le de traitement contre le cancer - Abdul Latif Jameel","robots":{"index":"noindex","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"og_locale":"fr_FR","og_type":"article","og_title":"Fa\u00e7onner un nouveau mod\u00e8le de traitement contre le cancer - Abdul Latif Jameel","og_description":"Republished from Abdul Latif Jameel Health Insights here. 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Charles Coombes, r\u00e9cemment nomm\u00e9 conseiller scientifique sp\u00e9cial aupr\u00e8s d\u2019Abdul Latif Jameel Health<\/h4>\r\n<p><em>Le dernier conseiller scientifique sp\u00e9cial \u00e0 rejoindre le conseil consultatif d\u2019<\/em><a href=\"https:\/\/aljhealth.com\"><em>Abdul Latif Jameel Health<\/em><\/a><em> est le <\/em><a href=\"https:\/\/aljhealth.com\/en\/our-people\/professor-charles-coombes-mbbs-frcp-md-fmedsci\/\"><em>professeur Charles Coombes<\/em><\/a><em>, une sommit\u00e9 mondiale reconnue dans le domaine du cancer, et plus particuli\u00e8rement du cancer du sein. Nous avons parl\u00e9 au professeur Collins de ses recherches, de son nouveau r\u00f4le chez Abdul Latif Jameel Health et de sa vision de l\u2019avenir des soins de sant\u00e9 mondiaux.<\/em><\/p>\r\n<p>Dans le cadre de sa mission visant \u00e0 faciliter l\u2019acc\u00e8s aux soins de sant\u00e9 modernes et de qualit\u00e9 dans le monde entier, Abdul Latif Jameel Health cherche continuellement \u00e0 \u00e9tablir des partenariats avec les plus grands innovateurs, organismes et chercheurs dans les secteurs mondiaux de la sant\u00e9.<\/p>\r\n\r\n[caption id=\"attachment_100922\" align=\"aligncenter\" width=\"1000\"]<img class=\"size-full wp-image-100922\" src=\"https:\/\/alj.com\/app\/uploads\/2022\/08\/Prof-Charles-Coombes-3.jpg\" alt=\"\" width=\"1000\" height=\"667\" \/> Professeur Charles Coombes (PhD, MBBS, FRCP, MD, FMedSci)[\/caption]\r\n\r\n<p><img class=\"alignright size-medium wp-image-100908\" src=\"https:\/\/alj.com\/app\/uploads\/2022\/08\/ICR-ICL-logos-300x55.jpg\" alt=\"\" width=\"300\" height=\"55\" \/>R. Charles Coombes est professeur d\u2019oncologie m\u00e9dicale \u00e0 l\u2019<a href=\"https:\/\/www.imperial.ac.uk\/people\/c.coombes\">Imperial College de Londres<\/a> et consultant honoraire en oncologie m\u00e9dicale \u00e0 l\u2019<a href=\"https:\/\/www.imperial.nhs.uk\/consultant-directory\/raoul-charles-coombes\">Imperial College Healthcare Trust<\/a>.<\/p>\r\n<p><img class=\"alignleft size-medium wp-image-100901\" src=\"https:\/\/alj.com\/app\/uploads\/2022\/08\/CRUK-logo-300x87.jpg\" alt=\"\" width=\"300\" height=\"87\" \/>Il est \u00e9galement pr\u00e9sident du <a href=\"https:\/\/www.bigagainstbreastcancer.org\/\">International Collaborative Cancer Group<\/a>, un centre d\u2019essais multinational (bas\u00e9 \u00e0 l\u2019Imperial College de Londres) ax\u00e9 sur les \u00e9tudes de phase\u00a0II et\u00a0III sur le cancer du sein, entre autres r\u00f4les de premier plan en oncologie.<\/p>\r\n<p>Fervent d\u00e9fenseur d\u2019une approche pluridisciplinaire de la recherche sur le cancer, le professeur Coombes a contribu\u00e9 \u00e0 la cr\u00e9ation du <a href=\"https:\/\/www.convergencesciencecentre.ac.uk\/\">Convergence Science Centre<\/a> \u00e0 l\u2019Imperial College en\u00a02020.<\/p>\r\n<p>Il dirige \u00e9galement un laboratoire translationnel qui se concentre sur la d\u00e9tection de la maladie microm\u00e9tastatique et son application au traitement du cancer du sein.\u00a0<\/p>\r\n<h2>Pourriez-vous fournir un aper\u00e7u de votre travail actuel ?<\/h2>\r\n<p><strong><img class=\"alignright size-medium wp-image-100915\" src=\"https:\/\/alj.com\/app\/uploads\/2022\/08\/ICR-ICL-exterior-300x195.jpg\" alt=\"\" width=\"300\" height=\"195\" \/>CC\u00a0: <\/strong>L\u2019une des initiatives les plus importantes auxquelles je participe actuellement est le Convergence Science Centre, un partenariat strat\u00e9gique entre l\u2019<a href=\"https:\/\/www.imperial.ac.uk\/\">Imperial College de Londres<\/a> et l\u2019<a href=\"https:\/\/www.icr.ac.uk\/\">Institute of Cancer Research de Londres<\/a>, qui a \u00e9t\u00e9 lanc\u00e9 il y a environ sept ans.<\/p>\r\n<p>Ce projet vise \u00e0 r\u00e9unir les comp\u00e9tences scientifiques de l\u2019Imperial College dans toute une s\u00e9rie de disciplines afin d\u2019aider les personnes atteintes de cancer.<\/p>\r\n<p>Les sciences les plus couramment utilis\u00e9es dans la d\u00e9tection et le traitement du cancer sont la biologie mol\u00e9culaire et cellulaire ainsi que la d\u00e9couverte de m\u00e9dicaments, mais il est d\u00e9sormais largement admis que cela ne suffit pas.<\/p>\r\n<p>Pour vraiment progresser dans la lutte contre cette maladie complexe, il faut \u00e9galement tirer parti des comp\u00e9tences les plus r\u00e9centes acquises dans d\u2019autres domaines scientifiques, comme la bio-ing\u00e9nierie, les math\u00e9matiques, la physique, les sciences d\u00e9mographiques, l\u2019informatique, etc., qui ont \u00e9t\u00e9 n\u00e9glig\u00e9es jusqu\u2019ici dans la recherche sur le cancer.<\/p>\r\n<p>Ce travail s\u2019est appuy\u00e9 sur le fait que j\u2019ai pass\u00e9 la moiti\u00e9 de ma carri\u00e8re \u00e0 l\u2019Institute of Cancer Research et au Royal Marsden Hospital de Londres, et l\u2019autre moiti\u00e9 \u00e0 l\u2019Imperial College. Il semblait logique que si nous pouvions r\u00e9unir ces deux grandes institutions, qui, ensemble, se classent probablement parmi les meilleures du Royaume-Uni (voire du monde) en termes d\u2019expertise sur le cancer, cela pourrait nous aider \u00e0 r\u00e9soudre ce probl\u00e8me.<\/p>\r\n<h2>Pouvez-vous nous expliquer comment fonctionne le Convergence Science Centre ?<\/h2>\r\n<p><strong>CC\u00a0: <\/strong>Il est triste de constater que, si le cancer touche pr\u00e8s de la moiti\u00e9 d\u2019entre nous, du moins en Occident, il est difficile de pr\u00e9dire quelle personne va d\u00e9velopper quel cancer. Et si un cancer se d\u00e9veloppe, il n\u2019est pas facile de pr\u00e9voir comment il va \u00e9voluer dans le corps humain. Cette incertitude signifie que nous ne pouvons exploiter au mieux les nouveaux traitements mol\u00e9culaires et les nouvelles technologies de diagnostic. Nous disposons aujourd\u2019hui d\u2019analyses sanguines et de tests d\u2019expectoration qui permettent de d\u00e9tecter le cancer \u00e0 un stade extr\u00eamement pr\u00e9coce, ainsi que d\u2019analyses de sang qui d\u00e9terminent comment le cancer \u00e9volue chez le patient. Mais tant que nous n\u2019aurons pas les moyens d\u2019enrichir ces technologies, nous ne pourrons pas les affiner pour les mettre \u00e0 la disposition de tous dans le monde.<\/p>\r\n<p>Le Convergence Science Centre contribue \u00e0 rassembler plusieurs disciplines scientifiques pour tenter de combler certaines lacunes dans des domaines cruciaux, comme les math\u00e9matiques extr\u00eamement complexes entourant la g\u00e9n\u00e9tique et l\u2019ADN.<\/p>\r\n<h2>Quels sont les avantages de cette approche ?<\/h2>\r\n<p><strong>CC\u00a0: <\/strong>Le traitement du cancer en Occident repose sur un ensemble de traitements plut\u00f4t toxiques comme la radioth\u00e9rapie, la chimioth\u00e9rapie cytotoxique, etc. Il s\u2019agit de technologies mal d\u00e9finies et non cibl\u00e9es qui, tout en combattant le cancer, endommagent \u00e9galement les cellules saines. Pour les pays en d\u00e9veloppement, l\u2019objectif est d\u2019\u00e9viter ces traitements potentiellement nocifs, et de recourir directement aux derni\u00e8res approches diagnostiques et th\u00e9rapeutiques modernes. Par exemple, l\u2019intelligence artificielle peut d\u00e9finir quels patients doivent faire l\u2019objet d\u2019un d\u00e9pistage, tandis que le type de cancer et son \u00e9volution peuvent tous \u00eatre diagnostiqu\u00e9s via des analyses de sang. Exit les syst\u00e8mes de radioth\u00e9rapie complexes et les grandes infrastructures de sant\u00e9. Ce dont nous aurons besoin \u00e0 l\u2019avenir, ce sont des technologies de diagnostic utilisables et des traitements cibl\u00e9s qui nous permettront d\u2019\u00e9viter le genre de traitements dommageables que les gens ont d\u00fb subir pour soigner leur cancer au cours des 50\u00a0derni\u00e8res ann\u00e9es.<\/p>\r\n<p>La combinaison d\u2019un diagnostic facile et d\u2019un traitement cibl\u00e9 apr\u00e8s une intervention chirurgicale est la solution pour am\u00e9liorer le taux de survie au cancer dans les pays en d\u00e9veloppement.<\/p>\r\n<h2>Quand avez-vous entendu parler d\u2019Abdul Latif Jameel Health pour la premi\u00e8re fois ?<\/h2>\r\n<p><strong>CC\u00a0: <\/strong>C\u2019est un nom que je connais depuis longtemps\u00a0; une organisation dont je savais qu\u2019elle s\u2019int\u00e9ressait \u00e0 l\u2019am\u00e9lioration de l\u2019acc\u00e8s aux soins de sant\u00e9 de qualit\u00e9 dans les march\u00e9s \u00e9mergents du Moyen-Orient, d\u2019Afrique et d\u2019Asie\u00a0: une question qui me tient profond\u00e9ment \u00e0 c\u0153ur. Je participe r\u00e9guli\u00e8rement \u00e0 des conf\u00e9rences et je suis invit\u00e9 \u00e0 donner des cours dans le monde entier, en particulier dans la r\u00e9gion MOAN, o\u00f9 Abdul Latif Jameel est un nom qui revient souvent. Aussi, lorsque l\u2019occasion s\u2019est pr\u00e9sent\u00e9e de m\u2019impliquer plus directement, j\u2019ai eu envie d\u2019en savoir plus.<\/p>\r\n<h2>En tant que conseiller scientifique sp\u00e9cial, qu\u2019esp\u00e9rez-vous apporter \u00e0 l\u2019organisation ?<\/h2>\r\n<p><strong>CC\u00a0: <\/strong>Je suis oncologue et chercheur en canc\u00e9rologie. Il y a un grand \u00e9cart entre ce que les gens d\u00e9couvrent dans les laboratoires et la mani\u00e8re dont ces d\u00e9couvertes sont mises en pratique en clinique, puis appliqu\u00e9es aux patients. Cet \u00e9cart est souvent ignor\u00e9, car les scientifiques passent toujours \u00e0 l\u2019\u00e9tape suivante de leurs recherches, pour affiner et am\u00e9liorer constamment leurs r\u00e9sultats.<\/p>\r\n<p>Il leur faut quelqu\u2019un comme moi, \u00e0 l\u2019Imperial College, qui analyse ce qu\u2019ils d\u00e9veloppent et puisse leur dire\u00a0: \u00ab\u00a0<em>Je sais que vous travaillez toujours dessus, mais d\u2019apr\u00e8s vos r\u00e9sultats vous \u00eates sur la bonne voie. Il n\u2019existe rien de tel, alors voyons si nous pouvons l\u2019utiliser pour aider les gens.\u00a0\u00bb<\/em> C\u2019est ce que j\u2019ai fait toute ma carri\u00e8re. Je participe depuis 40\u00a0ans \u00e0 la mise au point de nouveaux tests diagnostiques et m\u00e9dicaments contre le cancer (principalement le cancer du sein), et c\u2019est ce que je souhaite continuer \u00e0 faire dans le cadre de mon r\u00f4le au sein d\u2019Abdul Latif Jameel Health.<\/p>\r\n<h2>Abdul Latif Jameel Health se concentre particuli\u00e8rement sur l\u2019am\u00e9lioration de l\u2019acc\u00e8s aux soins de sant\u00e9 dans les pays en d\u00e9veloppement. Est-ce important pour vous ?<\/h2>\r\n<p><strong>CC\u00a0: <\/strong>Oui, absolument. C\u2019est un sujet qui me passionne. J\u2019ai, par exemple, donn\u00e9 des conf\u00e9rences au Nigeria, o\u00f9 il n\u2019y avait qu\u2019un seul centre anticanc\u00e9reux dot\u00e9 d\u2019un \u00e9quipement fonctionnel pour tout le pays, qui compte 160\u00a0millions d\u2019habitants. Je me suis rendu dans de nombreux pays de la r\u00e9gion o\u00f9 la pauvret\u00e9, les in\u00e9galit\u00e9s et le manque de capacit\u00e9 de diagnostic sont \u00e9normes.<\/p>\r\n<p>Outre l\u2019aspect financier, il y a souvent des obstacles culturels \u00e0 surmonter pour \u00e9duquer les gens sur le cancer et leur faire comprendre qu\u2019il n\u2019y a pas lieu d\u2019en avoir honte ou d\u2019en \u00eatre g\u00ean\u00e9.<\/p>\r\n<h2>Quels sont, selon vous, les plus grands d\u00e9fis de la recherche et du traitement contre le cancer ?<\/h2>\r\n<p><strong>CC\u00a0: <\/strong>Je pense que l\u2019\u00e9ducation est la chose la plus importante. Vous pouvez investir n\u2019importe quelle somme d\u2019argent, mais sans \u00e9ducation, elle n\u2019aura qu\u2019un impact limit\u00e9. La premi\u00e8re chose \u00e0 faire est d\u2019\u00e9duquer les gens sur les maladies et ce que l\u2019on peut faire pour y rem\u00e9dier. La priorit\u00e9 suivante est le d\u00e9pistage des personnes \u00e0 risque et l\u2019introduction d\u2019une sorte de parcours clair leur permettant d\u2019obtenir facilement de l\u2019aide. Dans une certaine mesure, une grande partie de ces activit\u00e9s pourrait \u00eatre r\u00e9alis\u00e9e \u00e0 distance gr\u00e2ce aux technologies modernes. L\u2019id\u00e9e que les gens aient \u00e0 parcourir des centaines de kilom\u00e8tres et patienter durant des heures dans un h\u00f4pital dans l\u2019espoir de voir un m\u00e9decin ne fonctionne pas dans le monde moderne.<\/p>\r\n<p>Une chose que la pand\u00e9mie de COVID-19 nous a apprise, c\u2019est que la communication \u00e0 travers le monde est beaucoup plus facile que nous le pensions. Nous devrions utiliser cette situation \u00e0 notre avantage pour rendre les soins de sant\u00e9 beaucoup plus accessibles sur les march\u00e9s qui en ont le plus besoin.<\/p>\r\n<h2>Comment des technologies comme l\u2019intelligence artificielle et le big data pourraient-elles contribuer \u00e0 am\u00e9liorer cette situation ?<\/h2>\r\n<p><strong>CC\u00a0: <\/strong>Ces types de technologies sont extr\u00eamement importants pour la lutte contre le cancer, et ils le sont de plus en plus. On parle parfois de l\u2019intelligence artificielle (IA) comme s\u2019il s\u2019agissait d\u2019une discipline \u00e0 part enti\u00e8re, mais ce n\u2019est pas le cas. Elle est d\u00e9j\u00e0 int\u00e9gr\u00e9e dans les travaux que de nombreux chercheurs et moi-m\u00eame r\u00e9alisons sur le cancer.<\/p>\r\n<p>La moiti\u00e9 des scientifiques que nous employons actuellement sont des sp\u00e9cialistes de l\u2019IA\u00a0; non seulement des math\u00e9maticiens de talent, mais des personnes qui appr\u00e9hendent aussi la g\u00e9n\u00e9tique, la biologie, le cancer, capables de combler ces \u00e9carts et de rassembler ces connaissances. Il s\u2019agit de recherche moderne sur le cancer, et c\u2019est ce que le Convergence Science Centre vise \u00e0 faire.<\/p>\r\n\r\n[caption id=\"attachment_100894\" align=\"aligncenter\" width=\"1912\"]<img class=\"size-full wp-image-100894\" src=\"https:\/\/alj.com\/app\/uploads\/2022\/08\/Cells.jpg\" alt=\"\" width=\"1912\" height=\"843\" \/> Cr\u00e9dit photo \u00a9 Cancer Research UK Imperial Centre[\/caption]\r\n\r\n<p>Une simple cellule est probablement plus complexe que tous les ordinateurs actuellement disponibles dans le monde. Dans une cuill\u00e8re \u00e0 caf\u00e9 de sang provenant d\u2019un patient canc\u00e9reux, on trouve plus d\u2019un million de fragments d\u2019ADN et d\u2019ARN, qui donnent tous des informations sur le type de cancer dont il est atteint et sur la mani\u00e8re de le traiter. Mais d\u00e9coder ces informations et leur donner un sens est impossible sans l\u2019IA. D\u00e9terminer quelles sous-populations ont une plus grande propension \u00e0 d\u00e9velopper un cancer et sont donc plus susceptibles de b\u00e9n\u00e9ficier d\u2019un d\u00e9pistage est un autre domaine critique o\u00f9 l\u2019IA est essentielle. Et puis, bien s\u00fbr, il y a les familles ayant des ant\u00e9c\u00e9dents de cancer, pour lesquelles l\u2019IA est essentielle pour nous aider \u00e0 comprendre la g\u00e9n\u00e9tique de la pr\u00e9disposition au cancer.<\/p>\r\n<p>Un autre domaine o\u00f9 l\u2019IA est essentielle est celui de la chimie et de l\u2019identification des cibles. Lorsque, par exemple, une analyse de sang indique la pr\u00e9sence d\u2019un cancer, son d\u00e9veloppement et sa division selon un certain type de facteur, il faut conna\u00eetre la structure de la prot\u00e9ine \u00e0 laquelle le m\u00e9dicament est cens\u00e9 se lier, afin d\u2019inhiber la prolif\u00e9ration du cancer chez ce patient. Cela est extraordinairement complexe et repose sur l\u2019IA \u00e0 pratiquement tous les stades du processus de d\u00e9couverte d\u2019un nouveau m\u00e9dicament.<\/p>\r\n<h2>Comment la pand\u00e9mie a-t-elle chang\u00e9 le discours sur les soins de sant\u00e9 mondiaux ?<\/h2>\r\n<p><strong>CC\u00a0: <\/strong>Je pense que cela l\u2019a chang\u00e9 de deux mani\u00e8res. Premi\u00e8rement, cela a d\u00e9montr\u00e9 aux gens que la science pouvait avoir un impact mondial. Les observateurs faisaient preuve d\u2019un certain cynisme \u00e0 l\u2019\u00e9gard de la science moderne avant la pand\u00e9mie, notamment en ce qui concerne le changement climatique. La pand\u00e9mie a montr\u00e9 l\u2019impact extr\u00eamement positif que peut avoir la science et la mani\u00e8re dont elle peut am\u00e9liorer les r\u00e9sultats en mati\u00e8re de sant\u00e9 pour les populations du monde entier.<\/p>\r\n<p>Deuxi\u00e8mement, la pand\u00e9mie a mis en \u00e9vidence l\u2019in\u00e9galit\u00e9 des soins de sant\u00e9 entre les diff\u00e9rentes r\u00e9gions du monde. La proportion de personnes vaccin\u00e9es dans les pays en d\u00e9veloppement est encore incroyablement faible, par exemple.<\/p>\r\n<p>Dans le domaine sp\u00e9cifique du cancer, on comprend de mieux en mieux que, de la m\u00eame mani\u00e8re que les virus \u00e9voluent et modifient leur g\u00e9n\u00e9tique pour surmonter les traitements, le cancer fait de m\u00eame. Les gens se sont habitu\u00e9s \u00e0 l\u2019id\u00e9e de s\u00e9quencer des virus et il en va de m\u00eame pour le cancer. Il convient de surveiller le cancer chez le patient pour pr\u00e9voir les traitements que vous allez lui administrer. C\u2019est tr\u00e8s similaire au d\u00e9veloppement de vaccins contre les virus mut\u00e9s.<\/p>\r\n<h2>Selon vous, comment Abdul Latif Jameel Health peut contribuer \u00e0 am\u00e9liorer cette situation et \u00e0 relever certains de ces d\u00e9fis ?<\/h2>\r\n<p><strong>CC\u00a0: <\/strong>Je pense qu\u2019Abdul Latif Jameel Health joue un r\u00f4le assez unique dans la mesure o\u00f9 elle s\u2019int\u00e9resse au diagnostic pr\u00e9coce et cherche \u00e0 doter les pays en d\u00e9veloppement mal desservis des derni\u00e8res avanc\u00e9es en mati\u00e8re de soins de sant\u00e9. Le <a href=\"https:\/\/alj.com\/en\/perspective\/democratizing-healthcare-scan-by-scan\/\">dispositif portatif \u00e0 ultrasons<\/a> Butterfly\u00a0iQ+, par exemple, est une technologie qui pourrait faire une \u00e9norme diff\u00e9rence sur de nombreux march\u00e9s gr\u00e2ce \u00e0 un diagnostic plus pr\u00e9coce.<\/p>\r\n\r\n[caption id=\"attachment_94228\" align=\"aligncenter\" width=\"2560\"]<img class=\"size-full wp-image-94228\" src=\"https:\/\/alj.com\/app\/uploads\/2021\/11\/ERM_4668.jpg\" alt=\"Butterfly Network\" width=\"2560\" height=\"1707\" \/> La sonde \u00e9chographique portative Butterfly\u00a0IQ+ en action (cr\u00e9dit photo \u00a9 Butterfly Network Inc.)[\/caption]\r\n\r\n<p>Le solide h\u00e9ritage d\u2019Abdul Latif Jameel dans la r\u00e9gion, ses connaissances, sa compr\u00e9hension et les partenariats existants constituent \u00e9galement un gros avantage pour introduire ces technologies sur le march\u00e9 et surmonter certains obstacles, qu\u2019ils soient d\u2019ordre culturel, pratique ou financier.<\/p>\r\n<h2>\u00cates-vous optimiste quant \u00e0 l\u2019avenir de la recherche sur le cancer et de son traitement ?<\/h2>\r\n<p><strong>CC\u00a0: <\/strong>Je ne suis pas objectif, car dans mon domaine, le cancer du sein, j\u2019ai vu le taux de gu\u00e9rison s\u2019am\u00e9liorer de fa\u00e7on spectaculaire tout au long de ma carri\u00e8re, donc en ce sens, je suis tr\u00e8s optimiste. S\u2019il existe encore de grandes diff\u00e9rences entre les taux de cancer du sein dans le monde, j\u2019ai bon espoir que dans dix ans, nous aurons consid\u00e9rablement am\u00e9lior\u00e9 le taux de gu\u00e9rison.<\/p>\r\n<p>D\u2019autres cancers, comme le cancer du poumon, le cancer du pancr\u00e9as, le cancer du cerveau ou le cancer de l\u2019estomac par exemple, sont tr\u00e8s difficiles \u00e0 traiter, notamment parce qu\u2019ils sont diagnostiqu\u00e9s trop tard. C\u2019est l\u00e0 que certaines de ces technologies autour des tests, du d\u00e9pistage et du diagnostic pr\u00e9coce sont vitales. Si nous parvenons \u00e0 les appliquer efficacement, elles pourraient changer la physionomie du traitement contre le cancer, en particulier dans les pays en d\u00e9veloppement.<\/p>\r\n<p>Je suis donc optimiste, mais il faut le faire \u00e0 une \u00e9chelle presque \u00ab\u00a0industrielle\u00a0\u00bb plut\u00f4t que de recourir aux m\u00e9thodes fragmentaires qui ont \u00e9t\u00e9 utilis\u00e9es jusqu\u2019\u00e0 pr\u00e9sent.<\/p>"],"_content":[""],"_ame_cpe_post_policy":["{\"accessProtection\":{\"active\":\"replace\"}}"],"_edit_last":["22"],"_wpml_media_duplicate":["1"],"_wpml_media_featured":["1"],"_yoast_wpseo_content_score":["30"],"_yoast_wpseo_estimated-reading-time-minutes":["1"]},"_links":{"self":[{"href":"https:\/\/cms.alj3.clients.lemonhq.io\/fr\/wp-json\/wp\/v2\/perspectives\/15673","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cms.alj3.clients.lemonhq.io\/fr\/wp-json\/wp\/v2\/perspectives"}],"about":[{"href":"https:\/\/cms.alj3.clients.lemonhq.io\/fr\/wp-json\/wp\/v2\/types\/perspectives"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cms.alj3.clients.lemonhq.io\/fr\/wp-json\/wp\/v2\/media\/15663"}],"wp:attachment":[{"href":"https:\/\/cms.alj3.clients.lemonhq.io\/fr\/wp-json\/wp\/v2\/media?parent=15673"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}