{"id":14860,"date":"2021-08-03T00:00:00","date_gmt":"2021-08-03T00:00:00","guid":{"rendered":"https:\/\/cms.alj3.clients.lemonhq.io\/perspectives\/stimuler-le-progres-grace-aux-partenariats\/"},"modified":"2026-05-12T11:39:15","modified_gmt":"2026-05-12T11:39:15","slug":"stimuler-le-progres-grace-aux-partenariats","status":"publish","type":"perspectives","link":"https:\/\/cms.alj3.clients.lemonhq.io\/fr\/perspectives\/stimuler-le-progres-grace-aux-partenariats\/","title":{"rendered":"Stimuler le progr\u00e8s gr\u00e2ce aux partenariats"},"content":{"rendered":"

A Q&A with Prof. James J. Collins, newly appointed special advisor to Abdul Latif Jameel Health<\/h4>\n

As part of its mission to improve accessibility to high quality healthcare around the world, Abdul Latif Jameel Health<\/a> is continually looking to forge partnerships with the leading organizations, researchers innovators and thinkers in the global biotech and health industries.<\/p>\n

In May 2021, it appointed Professor James J. Collins as a special advisor. \u00a0James is the Termeer Professor of Medical Engineering & Science<\/a> in the Institute for Medical Engineering & Science (IMES<\/a>) and Department of Biological Engineering at the Massachusetts Institute of Technology (MIT<\/a>).<\/p>\n

His innovative research group works in synthetic and systems biology, developing novel and pioneering ways to \u2018reprogram\u2019 organisms, including bacteria, to perform targeted tasks, such as detecting and treating infections. \u00a0This may lead to cheaper drugs, rapid diagnostic tests, and more effective treatments for antibiotic-resistant infections and a range of complex diseases.<\/p>\n

\"Meet

James Collins and Regina Barzilay (center) were named as inaugural faculty co-leads of the Abdul Latif Jameel Clinic for Machine Learning in Health, (Jameel Clinic), by Anantha Chandrakasan (right), Dean of MIT School of Engineering and Jameel Clinic Chair with Prof. Philip Sharp (left) Chair of the Clinic\u2019s advisory Board \u2013 October 2018.<\/p><\/div>\n

Along with MIT colleague Regina Barzilay, James is a faculty co-lead<\/a> of the Abdul Latif Jameel Clinic for Machine Learning in Health, (Jameel Clinic<\/a>) at MIT<\/a> since its founding in 2018.<\/p>\n

We spoke to Professor Collins about his research, his new role at Abdul Latif Jameel Health, and his vision for the future of global healthcare.<\/p>\n

Could you provide a brief overview of your current work?<\/h2>\n

I am the Termeer Professor of Medical Engineering and Science in the Institute for Medical Engineering and Science as well as the Department of Biological Engineering.\u00a0 I am also co-faculty lead of the Jameel Clinic, which was established with a generous gift from Mohammed Jameel<\/a> and his family to serve as a nexus point for efforts at MIT focused on applying AI to the challenges of healthcare.<\/p>\n

In addition to my position at MIT, I am also a founding core faculty member of the Wyss Institute at Harvard<\/a> and an Institute Member at the Broad Institute<\/a> of MIT and Harvard.\u00a0 My lab primarily focuses on two areas:\u00a0 synthetic biology and antibiotics research, two areas that are increasingly tapping into the potential of AI to advance our knowledge and capabilities.<\/p>\n

When did you first become aware of Abdul Latif Jameel Health?<\/h2>\n

I quickly became connected with Mohammed Jameel and the Jameel Family<\/a>, together with Community Jameel<\/a>, and their broader interests in translational healthcare research. \u00a0It was probably within a year of my involvement with the Jameel Clinic that I became aware of Abdul Latif Jameel Health<\/a> more specifically. \u00a0Its mission resonates closely with my own approach.\u00a0 I was delighted to be asked to join as an advisor.\u00a0 My role is primarily to help Abdul Latif Jameel Health evaluate exciting opportunities for either investment or partnerships, such as the recent link-ups with Evelo Biosciences<\/a> and Cellarity.<\/p>\n

What do you see as the biggest challenges facing global healthcare currently?<\/h2>\n

\"ProfMost people think of global health challenges as being exclusively around infectious diseases. \u00a0In my own field, we work in infectious diseases, particularly antibiotics and increasingly now antivirals as a result of the COVID-19 pandemic.\u00a0 But an under-appreciated aspect is that developing countries are also saddled with major challenges around non-infectious diseases, including cancer and nerve degenerative conditions.<\/p>\n

So, the bigger challenge is how to make the marvelous advances that we are seeing in both infectious and non-infectious diseases affordable and accessible to everybody.<\/p>\n

Traditionally, most of the effort around global public health has been in the non-profit sphere. \u00a0One of the missions of Abdul Latif Jameel Health is to see how it can be achieved from a for-profit<\/em> perspective, leveraging the ability of market forces and market encouragement to drive meaningful change.<\/p>\n

At a personal level, many of my interests are in infectious disease, but we are increasingly looking to see how various tools from AI and synthetic biology can address other more complex diseases and may lend themselves well to addressing broader health challenges around the globe.<\/p>\n

Could you provide some examples of how technologies like AI, big data and machine learning are advancing innovation on healthcare?<\/h2>\n
\"Halicin\"

The now famous MIT image showing Halicin (top) preventing antibiotic resistance in E. coli, ciprofloxacin (bottom) did not.<\/p>\n

Photo Credit \u00a9 courtesy Collins Lab at MIT<\/p><\/div>\n

If we take antibiotics first, as part of the Jameel Clinic, Regina Barzilay, Tommi Jaakkola and myself collaborated to see if we could harness the power of AI to address the antibiotic resistance crisis.\u00a0 We were able to advance a pilot effort where we trained an AI model to help us identify a potent new antibiotic called Halicin<\/a> that was very effective against a broad range of pathogens, including multi-drug resistant, extensively drug-resistant and pan-resistant pathogens.<\/p>\n

We were subsequently able to apply the model to an enormous library of 1.5 billion molecules in just a few days, identifying a large number of other new antibiotic candidates.<\/p>\n

We have now launched the Antibiotics-AI project at MIT through the Jameel Clinic, with the goal of using AI to design and discover a novel class of antibiotics, as we did with Halicin.<\/p>\n

On the synthetic biology side, we have previously established that you can use engineered synthetic gene circuits along with cell-free extracts.\u00a0 In the case of cell-free systems, you can open up a living cell and take the \u2018machinery\u2019 out of that cell.\u00a0 Our advance was to show you could freeze-dry these cell-free extract along with synthetic biology gene circuits onto paper in order to create inexpensive paper based diagnostics.<\/p>\n

Perhaps most stunningly, in the midst of the COVID-19 pandemic and under the auspices of the Jameel Clinic, in part, we showed we could use synthetic biology to create a COVID-19 facemask diagnostic that could give an output in a relatively few minutes with high sensitivity and high specificity to SARS-CoV-2.\u00a0 In short, a facemask which could tell you if you had COVID-19.<\/p>\n

How close to commercialization are these advances?<\/h2>\n

With Halicin, we are now advancing it further towards a potential clinical trial; exploring its toxicity, developing analogues to address the toxicity, and scoping out additional aspects of its drug-like properties.<\/p>\n

With regard to the paper-based diagnostic, we have a spinout from MIT, Sherlock Biosciences<\/a>, which has developed an FDA-approved COVID-19 diagnostic based on our synthetic biology platform<\/a>.\u00a0 This has now been adopted by multiple global diagnostic firms, as well as the country of Nepal as their national test. Sherlock Biosciences and its partners are now on pace to use our technology to conduct 10M COVID-19 diagnostic tests each month in countries around the globe.<\/p>\n

The diagnostic facemask is still at the academic stage.\u00a0 It is not yet commercialized, but it is an interesting opportunity to explore as to how could we move this from a lab demo at MIT and the Wyss Institute to a product that might be available at your local pharmacy.<\/p>\n

How important is it to make sure that innovations like these get out into the whole world and don\u2019t only become healthcare for wealthy nations?<\/h2>\n

It is an important part of my mission as a professor and an entrepreneur to try and ensure that our technologies are available to all.\u00a0 We too often see companies that are driven for profit over impact, particularly in the US.\u00a0 For me, impact is much more important than profit.\u00a0 I would much rather see a product that benefits millions of individuals than make millions of dollars off the product.<\/p>\n

Has the COVID-19 pandemic encouraged people to think more about this aspect?<\/h2>\n

It has, but not as much as it should.\u00a0 Greed is unfortunately a very powerful force in this world.<\/p>\n

\"221BThis is why, through Sherlock Biosciences, we have established a foundation called The 221b Foundation<\/a>, named after Sherlock Holmes\u2019 fictional address in London.<\/p>\n

We have committed to donating all profits from our COVID-19 product to the foundation, as well as making all our IP around CRISPR diagnostics available to any organization that would like to develop COVID-19 diagnostics, on the understanding that the profits need to come back to the foundation.<\/p>\n

These profits are then dedicated to advancing STEM (Science, Technology, Engineering and Mathematics) efforts for under-represented minorities, trying to encourage more young people to study STEM subjects, to advance technologies and to address global health challenges.<\/p>\n

How is the Jameel Clinic as a whole helping to address some of these issues?<\/h2>\n
\"Jameel

Hassan Jameel (L), L. Rafael Reif, President MIT (C) and Fady Jameel (R) at the foundation ceremony of the Jameel Clinic at MIT, 2018.<\/p><\/div>\n

The Jameel Clinic was formed approximately three years ago [2018], and it has been thriving since then, with a number of exciting programs underway.<\/p>\n

In the midst of the pandemic, the Clinic launched a program called AI Cures, which aims to advance AI to address emerging pathogens, including SARS-CoV-2.\u00a0 As part of this initiative, we were able to pull together a number of interesting datasets that were made accessible to researchers around the world.<\/p>\n

Working with Regina Barzilay and Tommi Jaakkola and a number of their graduate students, we were also able to use AI, for example, to develop effective combinations for treating SARS-CoV-2, the pathogen that causes COVID-19.<\/p>\n

What is it about AI, big data and machine learning that makes them such gamechangers in healthcare innovation?<\/h2>\n

The key aspect to AI and big data is that these resources enable us to embrace the complexity of biology and chemistry at a scale well beyond anything our brains alone could achieve.<\/p>\n

\"JamesEven the simplest of living cells, bacteria, are much more complicated than the most complicated machine we have ever designed on Earth.\u00a0 It is effectively impossible to comprehensively understand how such a living system evolved over the course of billions of years.<\/p>\n

Similarly, it is incredibly difficult to understand how a drug that we are developing could affect the complex biology of a living cell or set of cells.\u00a0 Big data and AI enable us to do that.\u00a0 We can use these technologies to query the biology of a living cell at a scale that we previously could not.\u00a0 It enables us to understand the interaction between molecules to generate better insights into how all these amazing components in a living cell interact to create a healthy state and how they might break down in their interactions to create a disease state.\u00a0 This allows us to identify how we could potentially intervene to correct or improve upon a diseased or injured state.<\/p>\n

Is the potential of these technologies yet fully understood?<\/h2>\n

Not at all, we are still very early days in applying AI to challenges in health care.\u00a0 We have seen AI and big data have a huge impact in the information world and the internet, but in the fields of biology and medicine, the age of big data is still in its infancy.\u00a0 I think we will see increasing advancements in the next decade or two as more and more data are collected and made available.\u00a0 One of our missions at the Jameel Clinic is to train the next generation of healthcare researchers to be multi-disciplinary, so they have expertise in both AI\/machine learning and in biology and chemistry, allowing them to work at the interface of technology, science and medicine to make breakthroughs that matter for patients.<\/p>\n

Looking ahead, what do you think the medium-to-longer-term future of global health care looks like?<\/h2>\n

I think one of the few advantages of the pandemic is a growing awareness among young people of the importance of infectious disease as a serious issue worthy of their attention. \u00a0So, I think we will see more young talent coming into the field of infectious diseases and global health, which will certainly advance our knowledge and our abilities to detect, treat and prevent infections.<\/p>\n

Looking ahead, we will certainly see dramatic, impressive changes and advances in biomedicine.\u00a0 We will see the growing impact of big data, advanced technologies including AI and synthetic biology, to advance efforts that enable us to better diagnose disease, treat disease, and prevent disease across the globe, in a way that is economically efficient and hopefully affordable to all.<\/p>\n","protected":false},"featured_media":14852,"menu_order":0,"template":"","class_list":["post-14860","perspectives","type-perspectives","status-publish","has-post-thumbnail","hentry"],"acf":[],"yoast_head":"\nStimuler le progr\u00e8s gr\u00e2ce aux partenariats - Abdul Latif Jameel<\/title>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Stimuler le progr\u00e8s gr\u00e2ce aux partenariats - Abdul Latif Jameel\" \/>\n<meta property=\"og:description\" content=\"A Q&A with Prof. James J. Collins, newly appointed special advisor to Abdul Latif Jameel Health As part of its mission to improve accessibility to high quality healthcare around the world, Abdul Latif Jameel Health is continually looking to forge partnerships with the leading organizations, researchers innovators and thinkers in the global biotech and health […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/cms.alj3.clients.lemonhq.io\/fr\/perspectives\/stimuler-le-progres-grace-aux-partenariats\/\" \/>\n<meta property=\"og:site_name\" content=\"Abdul Latif Jameel\" \/>\n<meta property=\"article:modified_time\" content=\"2026-05-12T11:39:15+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/media.alj3.clients.lemonhq.io\/wp-content\/uploads\/2024\/10\/Prof-James-J.-Collins.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"2067\" \/>\n\t<meta property=\"og:image:height\" content=\"1176\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Dur\u00e9e de lecture estim\u00e9e\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/cms.alj3.clients.lemonhq.io\/fr\/perspectives\/stimuler-le-progres-grace-aux-partenariats\/\",\"url\":\"https:\/\/cms.alj3.clients.lemonhq.io\/fr\/perspectives\/stimuler-le-progres-grace-aux-partenariats\/\",\"name\":\"Stimuler le progr\u00e8s gr\u00e2ce aux partenariats - Abdul Latif Jameel\",\"isPartOf\":{\"@id\":\"https:\/\/10.0.2.222\/en\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/cms.alj3.clients.lemonhq.io\/fr\/perspectives\/stimuler-le-progres-grace-aux-partenariats\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/cms.alj3.clients.lemonhq.io\/fr\/perspectives\/stimuler-le-progres-grace-aux-partenariats\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/media.alj3.clients.lemonhq.io\/wp-content\/uploads\/2024\/10\/Prof-James-J.-Collins.jpg\",\"datePublished\":\"2021-08-03T00:00:00+00:00\",\"dateModified\":\"2026-05-12T11:39:15+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/cms.alj3.clients.lemonhq.io\/fr\/perspectives\/stimuler-le-progres-grace-aux-partenariats\/#breadcrumb\"},\"inLanguage\":\"fr-FR\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/cms.alj3.clients.lemonhq.io\/fr\/perspectives\/stimuler-le-progres-grace-aux-partenariats\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"fr-FR\",\"@id\":\"https:\/\/cms.alj3.clients.lemonhq.io\/fr\/perspectives\/stimuler-le-progres-grace-aux-partenariats\/#primaryimage\",\"url\":\"https:\/\/media.alj3.clients.lemonhq.io\/wp-content\/uploads\/2024\/10\/Prof-James-J.-Collins.jpg\",\"contentUrl\":\"https:\/\/media.alj3.clients.lemonhq.io\/wp-content\/uploads\/2024\/10\/Prof-James-J.-Collins.jpg\",\"width\":2067,\"height\":1176},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/cms.alj3.clients.lemonhq.io\/fr\/perspectives\/stimuler-le-progres-grace-aux-partenariats\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/10.0.2.222\/en\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Stimuler le progr\u00e8s gr\u00e2ce aux partenariats\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/10.0.2.222\/en\/#website\",\"url\":\"https:\/\/10.0.2.222\/en\/\",\"name\":\"Abdul Latif Jameel\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/10.0.2.222\/en\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"fr-FR\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Stimuler le progr\u00e8s gr\u00e2ce aux partenariats - Abdul Latif Jameel","robots":{"index":"noindex","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"og_locale":"fr_FR","og_type":"article","og_title":"Stimuler le progr\u00e8s gr\u00e2ce aux partenariats - Abdul Latif Jameel","og_description":"A Q&A with Prof. James J. 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Collins, conseiller sp\u00e9cial r\u00e9cemment nomm\u00e9 \u00e0 Abdul Latif Jameel Health<\/h4>\r\n<p>Dans le cadre de sa mission visant \u00e0 am\u00e9liorer l\u2019accessibilit\u00e9 \u00e0 des soins de sant\u00e9 de haute qualit\u00e9 dans le monde entier, <a href=\"https:\/\/aljhealth.com\">Abdul Latif Jameel Health<\/a> cherche continuellement \u00e0 \u00e9tablir des partenariats avec les plus grands organismes, chercheurs, innovateurs et penseurs dans les secteurs mondiaux de la biotechnologie et de la sant\u00e9.<\/p>\r\n<p>En mai\u00a02021, le professeur James J. Collins a \u00e9t\u00e9 nomm\u00e9 comme conseiller sp\u00e9cial. James est <a href=\"https:\/\/be.mit.edu\/directory\/james-j-collins\">professeur titulaire d\u2019ing\u00e9nierie m\u00e9dicale et de science<\/a> \u00e0 l\u2019Institut d\u2019ing\u00e9nierie m\u00e9dicale et de science (<a href=\"https:\/\/imes.mit.edu\/\">IMES<\/a>) et au D\u00e9partement d\u2019ing\u00e9nierie biologique du Massachusetts Institute of Technology (<a href=\"https:\/\/mit.edu\/\">MIT<\/a>).<\/p>\r\n<p>Son groupe de recherche innovant travaille en biologie synth\u00e9tique et des syst\u00e8mes, d\u00e9veloppant des moyens novateurs de reprogrammer les organismes, y compris les bact\u00e9ries, pour effectuer des t\u00e2ches cibl\u00e9es, telles que la d\u00e9tection et le traitement des infections. Cela peut conduire \u00e0 des m\u00e9dicaments moins chers, des tests diagnostiques rapides et des traitements plus efficaces pour les infections r\u00e9sistantes aux antibiotiques et un \u00e9ventail de maladies complexes.<\/p>\r\n\r\n[caption id=\"attachment_53488\" align=\"alignright\" width=\"300\"]<img class=\"size-medium wp-image-53488\" src=\"https:\/\/www.alj.com\/app\/uploads\/2019\/11\/J-Clinic-Leadership-300x182.jpg\" alt=\"Meet the J-Clinic leadership team (L-R): Phillip A. Sharp, Chair, Advisory Board; James J. Collins & Regina Barizlay, Faculty Leads; Anantha P. Chandrakasan, Chair, J-Clinic.\" width=\"300\" height=\"182\" \/> James Collins et Regina Barzilay (au centre) ont \u00e9t\u00e9 nomm\u00e9s co-responsables du corps professoral inaugural de Abdul Latif Jameel Clinic pour l\u2019apprentissage automatique dans la sant\u00e9 (Jameel Clinic), par Anantha Chandrakasan (\u00e0 droite), doyen de l\u2019\u00c9cole d\u2019ing\u00e9nierie du MIT et pr\u00e9sident de Jameel Clinic avec le professeur Philip Sharp (\u00e0 gauche) du Conseil consultatif de la Clinique \u2013 octobre\u00a02018.[\/caption]\r\n\r\n<p>Avec sa coll\u00e8gue du MIT Regina Barzilay, James est un des <a href=\"https:\/\/news.mit.edu\/2018\/mit-barzilay-collins-sharp-lead-j-clinic-machine-learning-health-1003\">codirecteurs<\/a> de Abdul Latif Jameel Clinic pour l\u2019apprentissage automatique dans le domaine de la sant\u00e9, (<a href=\"https:\/\/www.jclinic.mit.edu\/\">Jameel Clinic<\/a>) au <a href=\"https:\/\/mit.edu\">MIT<\/a> depuis sa fondation en 2018.<\/p>\r\n<p>Nous avons parl\u00e9 au Professeur Collins de ses recherches, de son nouveau r\u00f4le chez Abdul Latif Jameel Health et de sa vision de l\u2019avenir des soins de sant\u00e9 mondiaux.<\/p>\r\n<h2>Pourriez-vous fournir un aper\u00e7u de votre travail actuel ?<\/h2>\r\n<p>Je suis professeur titulaire d\u2019ing\u00e9nierie m\u00e9dicale et de science \u00e0 l\u2019Institut d\u2019ing\u00e9nierie m\u00e9dicale et de science, ainsi qu\u2019au D\u00e9partement d\u2019ing\u00e9nierie biologique. Je suis \u00e9galement co-responsable de la Jameel Clinic qui a \u00e9t\u00e9 cr\u00e9\u00e9e gr\u00e2ce \u00e0 un g\u00e9n\u00e9reux don de <a href=\"https:\/\/www.alj.com\/en\/our-people\/mohammed-abdul-latif-jameel\/\">Mohammed Jameel<\/a> et de sa famille pour servir de point de convergence pour les efforts du MIT ax\u00e9s sur l\u2019application de l\u2019IA aux d\u00e9fis des soins de sant\u00e9.<\/p>\r\n<p>En plus de mon poste au MIT, je suis \u00e9galement membre fondateur du corps professoral de <a href=\"https:\/\/wyss.harvard.edu\/\">l\u2019Institut Wyss \u00e0 Harvard<\/a> et membre de l\u2019Institut au <a href=\"https:\/\/www.broadinstitute.org\/\">Broad Institute<\/a> du MIT et de Harvard. Mon laboratoire se concentre principalement sur deux domaines\u00a0: la biologie synth\u00e9tique et la recherche sur les antibiotiques, deux domaines qui exploitent de plus en plus le potentiel de l\u2019IA pour faire progresser nos connaissances et nos capacit\u00e9s.<\/p>\r\n<h2>Quand avez-vous entendu parler d\u2019Abdul Latif Jameel Health pour la premi\u00e8re fois ?<\/h2>\r\n<p>J\u2019ai rapidement \u00e9tabli un lien avec Mohammed Jameel et la <a href=\"https:\/\/www.communityjameel.org\/en\/who-we-are\/jameel-family\">famille Jameel<\/a>, ainsi qu\u2019avec <a href=\"https:\/\/www.communityjameel.org\">Community Jameel<\/a>, et leurs int\u00e9r\u00eats plus larges dans la recherche translationnelle en mati\u00e8re de soins de sant\u00e9. C\u2019\u00e9tait probablement dans l\u2019ann\u00e9e qui a suivi ma participation \u00e0 la Jameel Clinic que j\u2019ai eu connaissance <a href=\"https:\/\/aljhealth.com\">d\u2019Abdul Latif Jameel Health<\/a> plus sp\u00e9cifiquement. Sa mission r\u00e9sonne \u00e9troitement avec ma propre approche. J\u2019ai \u00e9t\u00e9 ravi d\u2019\u00eatre invit\u00e9 \u00e0 me joindre \u00e0 eux en tant que conseiller. Mon r\u00f4le consiste principalement \u00e0 aider Abdul Latif Jameel Health \u00e0 \u00e9valuer des opportunit\u00e9s passionnantes d\u2019investissement ou de partenariats, comme les liens r\u00e9cents avec <a href=\"https:\/\/www.alj.com\/en\/perspective\/a-stomach-for-innovation-a-qa-with-ceos-of-evelo-biosciences-and-abdul-latif-jameel-health-on-their-exciting-new-adventure\/\">Evelo Biosciences<\/a> et Cellarity.<\/p>\r\n<h2>Quels sont, selon vous, les plus grands d\u00e9fis auxquels le domaine des soins de sant\u00e9 mondiaux est actuellement confront\u00e9 ?<\/h2>\r\n<p><img class=\"alignleft size-medium wp-image-90854\" src=\"https:\/\/www.alj.com\/app\/uploads\/2021\/08\/Prof-James-J.-Collins-test-tube-192x300.jpg\" alt=\"Prof James J. Collins\" width=\"192\" height=\"300\" \/>La plupart des gens pensent que les d\u00e9fis sanitaires mondiaux sont exclusivement li\u00e9s aux maladies infectieuses. Dans mon propre domaine, nous travaillons sur les maladies infectieuses, en particulier les antibiotiques et de plus en plus aujourd\u2019hui les antiviraux \u00e0 la suite de la pand\u00e9mie de Covid-19. Mais un aspect sous-estim\u00e9 est que les pays en voie de d\u00e9veloppement sont \u00e9galement confront\u00e9s \u00e0 des d\u00e9fis majeurs concernant les maladies non infectieuses, y compris les cancers et les maladies d\u00e9g\u00e9n\u00e9ratives nerveuses.<\/p>\r\n<p>Donc, le plus grand d\u00e9fi est de savoir comment rendre les merveilleuses avanc\u00e9es que nous constatons sur les maladies infectieuses et non infectieuses abordables et accessibles \u00e0 tous.<\/p>\r\n<p>Traditionnellement, la plupart des efforts autour de la sant\u00e9 publique mondiale se situaient dans la sph\u00e8re des organismes \u00e0 but non lucratif. L\u2019une des missions d\u2019Abdul Latif Jameel Health est de voir comment cela peut \u00eatre r\u00e9alis\u00e9 d\u2019un point de vue <em>lucratif<\/em>, en tirant parti de la capacit\u00e9 des forces du march\u00e9 et de l\u2019encouragement du march\u00e9 \u00e0 conduire un changement significatif.<\/p>\r\n<p>\u00c0 un niveau personnel, nombre de mes int\u00e9r\u00eats portent sur les maladies infectieuses, mais nous cherchons de plus en plus \u00e0 voir comment divers outils de l\u2019IA et de la biologie synth\u00e9tique peuvent traiter d\u2019autres maladies plus complexes et peuvent se pr\u00eater \u00e0 relever des d\u00e9fis de sant\u00e9 plus larges dans le monde entier.<\/p>\r\n<h2>Pourriez-vous fournir quelques exemples de la fa\u00e7on dont les technologies comme l\u2019IA, le Big Data et l\u2019apprentissage machine font progresser l\u2019innovation dans le domaine des soins de sant\u00e9 ?<\/h2>\r\n\r\n[caption id=\"attachment_57744\" align=\"alignright\" width=\"300\"]<img class=\"size-medium wp-image-57744\" src=\"https:\/\/www.alj.com\/app\/uploads\/2020\/02\/halicin-antibiotics-300x300.jpg\" alt=\"Halicin\" width=\"300\" height=\"300\" \/> La d\u00e9sormais c\u00e9l\u00e8bre image du MIT montrant que l\u2019halicin (en haut) pr\u00e9vient la r\u00e9sistance aux antibiotiques pour la bact\u00e9rie E.\u00a0coli, alors que la ciprofloxacine (en bas) ne le fait pas.<br \/>\r\nCr\u00e9dit photo \u00a9 avec l\u2019aimable autorisation du Collins Lab au MIT[\/caption]\r\n\r\n<p>Si nous prenons d\u2019abord les antibiotiques, dans le cadre de la Jameel Clinic, Regina Barzilay, Tommi Jaakkola et moi-m\u00eame avons collabor\u00e9 pour voir si nous pouvions exploiter le pouvoir de l\u2019IA pour traiter la crise de r\u00e9sistance aux antibiotiques. Nous avons pu faire avancer un effort pilote o\u00f9 nous avons form\u00e9 un mod\u00e8le d\u2019IA pour nous aider \u00e0 identifier un nouvel antibiotique puissant, appel\u00e9 <a href=\"https:\/\/www.alj.com\/en\/news\/j-clinic-discovers-powerful-new-antibiotic-using-ai-technology\/\">halicin<\/a>, qui \u00e9tait tr\u00e8s efficace contre un large \u00e9ventail de pathog\u00e8nes, y compris les pathog\u00e8nes multir\u00e9sistants, fortement r\u00e9sistants aux m\u00e9dicaments et pan-r\u00e9sistants.<\/p>\r\n<p>Nous avons ensuite pu appliquer le mod\u00e8le \u00e0 une \u00e9norme biblioth\u00e8que de 1,5\u00a0milliard de mol\u00e9cules en quelques jours seulement, identifiant un grand nombre d\u2019autres nouveaux candidats antibiotiques.<\/p>\r\n<p>Nous avons maintenant lanc\u00e9 le projet Antibiotics-AI au MIT par l\u2019interm\u00e9diaire de la Jameel Clinic, dans le but d\u2019utiliser l\u2019IA pour concevoir et d\u00e9couvrir une nouvelle classe d\u2019antibiotiques, comme nous l\u2019avons fait avec l\u2019halicin.<\/p>\r\n<p>En ce qui concerne la biologie synth\u00e9tique, nous avons d\u00e9j\u00e0 \u00e9tabli que l\u2019on peut utiliser des circuits g\u00e9n\u00e9tiques synth\u00e9tiques et des extraits de cellules. Dans le cas des syst\u00e8mes sans cellules, vous pouvez ouvrir une cellule vivante et retirer la \u00ab\u00a0machinerie\u00a0\u00bb de cette cellule. Notre avanc\u00e9e a permis de montrer qu\u2019il \u00e9tait possible de lyophiliser ces extraits cellulaires ainsi que des circuits g\u00e9n\u00e9tiques de biologie synth\u00e9tique sur du papier afin de cr\u00e9er des diagnostics peu co\u00fbteux sur papier.<\/p>\r\n<p>Ce qui est peut-\u00eatre le plus \u00e9tonnant, c\u2019est qu\u2019au milieu de la pand\u00e9mie de Covid-19 et sous les auspices de la Jameel Clinic, nous avons montr\u00e9 que nous pouvions utiliser la biologie synth\u00e9tique pour cr\u00e9er un masque de diagnostic du Covid-19 qui pouvait donner un r\u00e9sultat en quelques minutes avec une haute sensibilit\u00e9 et une haute sp\u00e9cificit\u00e9 pour le SRAS-CoV-2. En bref, un masque facial qui pourrait vous dire si vous avez eu le Covid-19.<\/p>\r\n<h2>Dans quelle mesure ces progr\u00e8s sont-ils proches de la commercialisation ?<\/h2>\r\n<p>En ce qui concerne l\u2019halicin, nous sommes en train de le faire progresser vers un essai clinique potentiel, d\u2019explorer sa toxicit\u00e9, de d\u00e9velopper des analogues pour rem\u00e9dier \u00e0 cette toxicit\u00e9 et d\u2019\u00e9tudier d\u2019autres aspects de ses propri\u00e9t\u00e9s de type m\u00e9dicamenteux.<\/p>\r\n<p>En ce qui concerne le diagnostic sur papier, nous avons une entreprise d\u00e9riv\u00e9e du MIT, <a href=\"https:\/\/sherlock.bio\/\">Sherlock Biosciences<\/a>, qui a d\u00e9velopp\u00e9 <a href=\"https:\/\/sherlock.bio\/sherlock-biosciences-receives-fda-emergency-use-authorization-for-crispr-sars-cov-2-rapid-diagnostic\/\">un diagnostic de Covid-19 approuv\u00e9 par la FDA bas\u00e9 sur notre plateforme de biologie synth\u00e9tique<\/a>. Cela a maintenant \u00e9t\u00e9 adopt\u00e9 par plusieurs entreprises mondiales de diagnostic, ainsi que par le N\u00e9pal comme test national. Sherlock Biosciences et ses partenaires sont maintenant en phase avec l\u2019utilisation de notre technologie pour effectuer 10\u00a0millions de tests diagnostiques de la Covid-19 chaque mois dans des pays du monde entier.<\/p>\r\n<p>Le masque de diagnostic est toujours au stade acad\u00e9mique. Il n\u2019est pas encore commercialis\u00e9, mais c\u2019est une opportunit\u00e9 int\u00e9ressante d\u2019explorer comment nous pourrions le faire passer d\u2019une d\u00e9monstration en laboratoire au MIT et \u00e0 l\u2019Institut Wyss \u00e0 un produit qui pourrait \u00eatre disponible dans votre pharmacie locale.<\/p>\r\n<h2>Dans quelle mesure est-il important de s\u2019assurer que ces innovations profitent au monde entier et ne deviennent pas uniquement des soins de sant\u00e9 pour les nations ais\u00e9es ?<\/h2>\r\n<p>C\u2019est une partie importante de ma mission en tant que professeur et entrepreneur de s\u2019assurer que nos technologies soient accessibles \u00e0 tous. Trop souvent, nous voyons des entreprises plus motiv\u00e9es par les b\u00e9n\u00e9fices que par l\u2019impact, en particulier aux \u00c9tats-Unis. Pour moi, l\u2019impact est beaucoup plus important que les b\u00e9n\u00e9fices. Je pr\u00e9f\u00e9rerais de loin voir un produit qui profite \u00e0 des millions d\u2019individus plut\u00f4t que de gagner des millions de dollars avec le produit.<\/p>\r\n<h2>La pand\u00e9mie de Covid-19 a-t-elle encourag\u00e9 les personnes \u00e0 r\u00e9fl\u00e9chir davantage \u00e0 cet aspect ?<\/h2>\r\n<p>Oui, mais pas autant que cela devrait l\u2019\u00eatre. La cupidit\u00e9 est malheureusement une force tr\u00e8s puissante dans ce monde.<\/p>\r\n<p><img class=\"alignright size-full wp-image-90847\" src=\"https:\/\/www.alj.com\/app\/uploads\/2021\/08\/Logo.jpg\" alt=\"221B Foundation Logo\" width=\"195\" height=\"88\" \/>C\u2019est pourquoi, gr\u00e2ce \u00e0 Sherlock Biosciences, nous avons \u00e9tabli une fondation appel\u00e9e <u>The <\/u><a href=\"https:\/\/221bfoundation.org\/\">221b Foundation<\/a>, nomm\u00e9e d\u2019apr\u00e8s l\u2019adresse fictive de Sherlock Holmes \u00e0 Londres.<\/p>\r\n<p>Nous nous sommes engag\u00e9s \u00e0 reverser tous les b\u00e9n\u00e9fices de notre produit Covid-19 \u00e0 la fondation, ainsi qu\u2019\u00e0 mettre toute notre propri\u00e9t\u00e9 intellectuelle autour des diagnostics CRISPR \u00e0 la disposition de toute organisation qui souhaiterait d\u00e9velopper des diagnostics Covid-19, \u00e9tant entendu que les b\u00e9n\u00e9fices doivent revenir \u00e0 la fondation.<\/p>\r\n<p>Ces b\u00e9n\u00e9fices servent ensuite \u00e0 financer les efforts en mati\u00e8re de STIM (sciences, technologies, ing\u00e9nierie et math\u00e9matiques) pour les minorit\u00e9s sous-repr\u00e9sent\u00e9es, en essayant d\u2019encourager davantage de jeunes \u00e0 \u00e9tudier les mati\u00e8res STIM, \u00e0 faire progresser les technologies et \u00e0 relever les d\u00e9fis de la sant\u00e9 mondiale.<\/p>\r\n<h2>Comment la Jameel Clinic dans son ensemble contribue-t-elle \u00e0 r\u00e9soudre certains de ces probl\u00e8mes ?<\/h2>\r\n\r\n[caption id=\"attachment_53566\" align=\"alignright\" width=\"300\"]<img class=\"size-medium wp-image-53566\" src=\"https:\/\/www.alj.com\/app\/uploads\/2019\/11\/Hassan-Jameel-JClinic-300x200.jpg\" alt=\"Jameel Clinic\" width=\"300\" height=\"200\" \/> Hassan Jameel (L), L. Rafael Reif, pr\u00e9sident du MIT (C) et Fady Jameel (R) lors de la c\u00e9r\u00e9monie d\u2019inauguration de la Jameel Clinic au MIT, 2018.[\/caption]\r\n\r\n<p>La Jameel Clinic a \u00e9t\u00e9 cr\u00e9\u00e9e il y a environ trois ans [2018], et elle s\u2019est d\u00e9velopp\u00e9e depuis, avec un certain nombre de programmes passionnants en cours.<\/p>\r\n<p>Au milieu de la pand\u00e9mie, la clinique a lanc\u00e9 un programme appel\u00e9 AI Cures, qui vise \u00e0 faire progresser l\u2019IA pour traiter les agents pathog\u00e8nes \u00e9mergents, y compris le SRAS-CoV-2. Dans le cadre de cette initiative, nous avons pu rassembler un certain nombre d\u2019ensembles de donn\u00e9es int\u00e9ressants qui ont \u00e9t\u00e9 mis \u00e0 la disposition des chercheurs du monde entier.<\/p>\r\n<p>En travaillant avec Regina Barzilay et Tommi Jaakkola et un certain nombre de leurs \u00e9tudiants dipl\u00f4m\u00e9s, nous avons \u00e9galement pu utiliser l\u2019IA, par exemple, pour d\u00e9velopper des combinaisons efficaces pour traiter le SRAS-CoV-2, le pathog\u00e8ne responsable du Covid-19.<\/p>\r\n<h2>Qu\u2019est-ce qui fait de l\u2019IA, du big data et de l\u2019apprentissage machine des acteurs de l\u2019innovation dans le domaine des soins de sant\u00e9 ?<\/h2>\r\n\r\n[caption id=\"attachment_87906\" align=\"alignleft\" width=\"300\"]<img class=\"size-medium wp-image-87906\" src=\"https:\/\/www.alj.com\/app\/uploads\/2021\/04\/James-J-Collins-T-300x162.jpg\" alt=\"James J Collins\" width=\"300\" height=\"162\" \/> James J Collins[\/caption]\r\n\r\n<p>L\u2019aspect cl\u00e9 de l\u2019IA et des big data est que ces ressources nous permettent d\u2019adopter la complexit\u00e9 de la biologie et de la chimie \u00e0 une \u00e9chelle bien sup\u00e9rieure \u00e0 tout ce que nos cerveaux seuls pourraient r\u00e9aliser.<\/p>\r\n<p>M\u00eame les cellules vivantes les plus simples, les bact\u00e9ries, sont beaucoup plus compliqu\u00e9es que la machine la plus compliqu\u00e9e que nous ayons jamais con\u00e7ue sur Terre. Il est effectivement impossible de comprendre de mani\u00e8re exhaustive comment un tel syst\u00e8me vivant a \u00e9volu\u00e9 au cours de milliards d\u2019ann\u00e9es.<\/p>\r\n<p>De m\u00eame, il est incroyablement difficile de comprendre comment un m\u00e9dicament que nous d\u00e9veloppons pourrait affecter la biologie complexe d\u2019une cellule vivante ou d\u2019un ensemble de cellules. Les m\u00e9gadonn\u00e9es et l\u2019IA nous permettent d\u2019y parvenir. Nous pouvons utiliser ces technologies pour interroger la biologie d\u2019une cellule vivante \u00e0 une \u00e9chelle jamais atteinte auparavant. Cela nous permet de comprendre l\u2019interaction entre les mol\u00e9cules pour g\u00e9n\u00e9rer de meilleures informations sur la fa\u00e7on dont tous ces composants incroyables d\u2019une cellule vivante interagissent pour cr\u00e9er un \u00e9tat sain et comment ils pourraient se d\u00e9composer dans leurs interactions pour cr\u00e9er un \u00e9tat pathologique. Cela nous permet d\u2019identifier comment nous pourrions potentiellement intervenir pour corriger ou am\u00e9liorer un \u00e9tat malade ou bless\u00e9.<\/p>\r\n<h2>Le potentiel de ces technologies est-il d\u00e9j\u00e0 pleinement compris?<\/h2>\r\n<p>Pas du tout, nous n\u2019en sommes qu\u2019aux pr\u00e9mices de l\u2019application de l\u2019IA aux d\u00e9fis des soins de sant\u00e9. Nous avons pu constater l\u2019impact \u00e9norme de l\u2019IA et du big data dans le monde de l\u2019information et sur Internet, mais dans les domaines de la biologie et de la m\u00e9decine, l\u2019\u00e8re du big data n\u2019en est encore qu\u2019\u00e0 ses balbutiements. Je pense que nous verrons des progr\u00e8s croissants au cours de la prochaine d\u00e9cennie ou des deux prochaines ann\u00e9es, car de plus en plus de donn\u00e9es sont collect\u00e9es et mises \u00e0 disposition. L\u2019une de nos missions \u00e0 la Jameel Clinic est de former la prochaine g\u00e9n\u00e9ration de chercheurs en soins de sant\u00e9 \u00e0 \u00eatre pluridisciplinaire, afin qu\u2019ils aient une expertise \u00e0 la fois en IA\/apprentissage machine et en biologie et chimie, leur permettant de travailler \u00e0 l\u2019interface de la technologie, de la science et de la m\u00e9decine pour r\u00e9aliser des avanc\u00e9es qui comptent pour les patients.<\/p>\r\n<h2>\u00c0 quoi ressemble, selon vous, l\u2019avenir des soins de sant\u00e9 mondiaux \u00e0 moyen et long terme ?<\/h2>\r\n<p>Je pense que l\u2019un des quelques avantages de la pand\u00e9mie est une sensibilisation croissante des jeunes \u00e0 l\u2019importance des maladies infectieuses comme un probl\u00e8me s\u00e9rieux qui m\u00e9rite leur attention. Je pense donc que nous verrons plus de jeunes talents entrer dans le domaine des maladies infectieuses et de la sant\u00e9 mondiale, ce qui fera certainement progresser nos connaissances et nos capacit\u00e9s \u00e0 d\u00e9tecter, traiter et pr\u00e9venir les infections.<\/p>\r\n<p>\u00c0 l\u2019avenir, nous verrons certainement des changements et des progr\u00e8s spectaculaires et impressionnants dans la biom\u00e9decine. Nous verrons l\u2019impact croissant des m\u00e9gadonn\u00e9es, des technologies avanc\u00e9es, y compris l\u2019IA et la biologie synth\u00e9tique, pour faire progresser les efforts qui nous permettent de mieux diagnostiquer les maladies, de les traiter et de les pr\u00e9venir \u00e0 travers le monde, d\u2019une mani\u00e8re \u00e9conomiquement efficace et, nous l\u2019esp\u00e9rons, abordable pour tous.<\/p>"],"_content":[""],"_ame_cpe_post_policy":["{\"accessProtection\":{\"active\":\"replace\"}}"],"_edit_last":["22"],"_wpml_media_duplicate":["1"],"_wpml_media_featured":["1"],"_yoast_wpseo_content_score":["90"],"_yoast_wpseo_estimated-reading-time-minutes":["1"]},"_links":{"self":[{"href":"https:\/\/cms.alj3.clients.lemonhq.io\/fr\/wp-json\/wp\/v2\/perspectives\/14860","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cms.alj3.clients.lemonhq.io\/fr\/wp-json\/wp\/v2\/perspectives"}],"about":[{"href":"https:\/\/cms.alj3.clients.lemonhq.io\/fr\/wp-json\/wp\/v2\/types\/perspectives"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cms.alj3.clients.lemonhq.io\/fr\/wp-json\/wp\/v2\/media\/14852"}],"wp:attachment":[{"href":"https:\/\/cms.alj3.clients.lemonhq.io\/fr\/wp-json\/wp\/v2\/media?parent=14860"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}